Assay Detail
Functional
CHEMBL695548
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In vitro ability to inhibit cholesterol biosynthesis in HepG2 cells in culture from [14C]acetate.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
(Aryloxy)methylsilane derivatives as new cholesterol biosynthesis inhibitors: synthesis and hypocholesterolemic activity of a new class of squalene epoxidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.97 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15929 | — | — | 1 | 7.16 |
| CHEMBL107568 | — | — | 1 | 6.92 |
| CHEMBL108692 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15929 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL107568 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL108692 | — | IC50 | = | 150.0 | nM | 6.82 |