Assay Detail
Binding
CHEMBL661140
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of human Cytochrome P450 17A1 activity
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL3522) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Three dimensional pharmacophore modeling of human CYP17 inhibitors. Potential agents for prostate cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.66 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL277535 | BIFONAZOLE | 3.0 | 1 | 7.25 |
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 1 | 7.09 |
| CHEMBL91 | MICONAZOLE | 4.0 | 1 | 6.61 |
| CHEMBL808 | ECONAZOLE | 4.0 | 1 | 6.49 |
| CHEMBL1200438 | TIOCONAZOLE | 4.0 | 1 | 6.30 |
| CHEMBL1571863 | ISOCONAZOLE | 2.0 | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL277535 | BIFONAZOLE | Ki | = | 56.5 | nM | 7.25 |
| CHEMBL104 | CLOTRIMAZOLE | Ki | = | 81.5 | nM | 7.09 |
| CHEMBL91 | MICONAZOLE | Ki | = | 243.0 | nM | 6.61 |
| CHEMBL808 | ECONAZOLE | Ki | = | 325.0 | nM | 6.49 |
| CHEMBL1200438 | TIOCONAZOLE | Ki | = | 505.0 | nM | 6.30 |
| CHEMBL1571863 | ISOCONAZOLE | Ki | = | 610.0 | nM | 6.21 |