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Target Snapshot

CHEMBL612790 Target Snapshot

Leishmania chagasi · ORGANISM · Leishmania chagasi

Back to Search Search this target Browse approvals Evidence Card
178Compounds
46Assays
7Approved Drugs
220.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Leishmania chagasi as ChEMBL target CHEMBL612790. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Leishmania chagasi
ORGANISM · Leishmania chagasi
As of 2026-09-14
ChEMBL target ID
CHEMBL612790
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Leishmania chagasi still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameLeishmania chagasi
Target TypeORGANISM
OrganismLeishmania chagasi
ChEMBL ↗ NCBI Taxonomy ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelLeishmania chagasi
UniProt AccessionN/A

Leishmania chagasi

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Leishmania chagasi.

Review nameLeishmania chagasi
OrganismLeishmania chagasi
Clinical Profile

Clinical Phase Distribution

7
Approved
5
Phase III
Assay Mix

Activity Type Distribution

IC50218.0
EC502.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL267345 8.0 IC50 10.0 Approved
CHEMBL108323 6.7 IC50 200.0 Preclinical
CHEMBL239272 6.35 IC50 450.0 Preclinical
CHEMBL180844 6.3 IC50 500.0 Preclinical
CHEMBL394918 6.28 IC50 530.0 Preclinical
CHEMBL5271084 6.28 IC50 530.0 Preclinical
CHEMBL240549 6.25 IC50 560.0 Preclinical
CHEMBL55 5.96 IC50 1110.0 Approved
CHEMBL2047341 5.85 IC50 1400.0 Preclinical
CHEMBL56756 5.72 IC50 1910.0 Preclinical
Distribution

pChEMBL Value Distribution

9
5.0
14
5.5
6
6.0
2
6.5
1
7.0
1
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

AMPHOTERICIN B
CHEMBL267345
Approved 1964
Properties Compare Identifier
Assay Landscape

Assay Landscape

46
Total Assays
105
Tested Compounds
1
Assay Types
Functional — 46 assays, 105 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 43 101 4.9
assay format 3 4 5.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine