Lanosterol 14-alpha demethylase · SINGLE PROTEIN · Homo sapiens
This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.
Move to another high-traffic target or paste a specific ChEMBL target ID.
Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13Protein identity stays anchored to UniProt Q16850. Use UniProt Q16850 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q16850 as the stable identity anchor, then attach disease evidence before program review.
Lanosterol 14-alpha demethylase
Review this target as Lanosterol 14-alpha demethylase, mapped to UniProt Q16850. Sequence length is 509 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Lanosterol 14-alpha demethylase as ChEMBL target CHEMBL3849, mapped to UniProt Q16850. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Lanosterol 14-alpha demethylase is the right protein anchor across sources, using UniProt Q16850 as the stable mapping.
Jump to Protein ContextUse this block first when you need the strongest disease program and evidence level in one place.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Lanosterol 14-alpha demethylase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q16850 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Lanosterol 14-alpha demethylase |
| UniProt Accession | Q16850 |
| Component Type | Protein |
| Sequence Length | 509 aa |
Lanosterol 14-alpha demethylase
Review this target as Lanosterol 14-alpha demethylase, mapped to UniProt Q16850. Sequence length is 509 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL305220 | 7.75 | Ki | 17.7 | Preclinical |
| CHEMBL4461447 | 7.7 | Kd | 20.0 | Preclinical |
| CHEMBL157101 | 7.61 | Ki | 24.5 | Approved |
| CHEMBL808 | 7.3 | IC50 | 50.0 | Approved |
| CHEMBL4277680 | 7.22 | Kd | 60.0 | Preclinical |
| CHEMBL4522116 | 7.05 | Kd | 90.0 | Preclinical |
| CHEMBL3629567 | 7.05 | Kd | 90.0 | Preclinical |
| CHEMBL157101 | 6.96 | Kd | 110.0 | Approved |
| CHEMBL104 | 6.89 | IC50 | 130.0 | Approved |
| CHEMBL4439225 | 6.89 | Kd | 130.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 10 | 6 | 5.2 |
| assay format | 7 | 21 | 5.8 |
| cell-based format | 2 | 24 | 5.4 |
| microsome format | 2 | 2 | 7.5 |