Assay Detail
Functional
CHEMBL4054069
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against Leishmania infantum chagasi MHOM/BR/1972/LD promastigote forms infected in golden hamster after 48 hrs by Alamar Blue assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania chagasi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
An overview of azoles targeting sterol 14α-demethylase for antileishmanial therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.29 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 1 | 5.55 |
| CHEMBL808 | ECONAZOLE | 4.0 | 1 | 5.27 |
| CHEMBL277535 | BIFONAZOLE | 3.0 | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104 | CLOTRIMAZOLE | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL808 | ECONAZOLE | IC50 | = | 5360.0 | nM | 5.27 |
| CHEMBL277535 | BIFONAZOLE | IC50 | = | 8970.0 | nM | 5.05 |