Assay Detail
Functional
CHEMBL3392944
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DNDI: Malaria in Vitro, 72 hour
89
Total Activities
87
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 89 | 5.62 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL172 | (S,R)-MEFLOQUINE | — | 1 | 8.62 |
| CHEMBL3039774 | — | — | 1 | 8.52 |
| CHEMBL57004 | SITAMAQUINE | 2.0 | 1 | 7.10 |
| CHEMBL3392927 | — | — | 1 | 7.00 |
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 1 | 6.96 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.77 |
| CHEMBL3392933 | — | — | 1 | 6.57 |
| CHEMBL808 | ECONAZOLE | 4.0 | 1 | 6.50 |
| CHEMBL564 | PROMAZINE | 4.0 | 1 | 6.31 |
| CHEMBL91 | MICONAZOLE | 4.0 | 1 | 6.31 |
| CHEMBL726 | FLUPHENAZINE | 4.0 | 1 | 6.30 |
| CHEMBL809 | SERTRALINE | 4.0 | 1 | 6.29 |
| CHEMBL437765 | RIFAMYCIN | 4.0 | 1 | 6.26 |
| CHEMBL445 | NORTRIPTYLINE | 4.0 | 1 | 6.24 |
| CHEMBL1200438 | TIOCONAZOLE | 4.0 | 2 | 6.20 |
| CHEMBL534 | KETOTIFEN | 4.0 | 1 | 6.12 |
| CHEMBL487366 | — | — | 1 | 6.10 |
| CHEMBL415087 | CLOPERASTINE | 2.0 | 1 | 6.06 |
| CHEMBL3392928 | — | — | 1 | 6.04 |
| CHEMBL3392935 | — | — | 1 | 6.01 |
| CHEMBL1448 | NICLOSAMIDE | 4.0 | 1 | 5.94 |
| CHEMBL629 | AMITRIPTYLINE | 4.0 | 1 | 5.94 |
| CHEMBL1113 | AMOXAPINE | 4.0 | 1 | 5.94 |
| CHEMBL1169388 | — | — | 1 | 5.92 |
| CHEMBL932 | DIPYRIDAMOLE | 4.0 | 1 | 5.89 |
| CHEMBL415 | CLOMIPRAMINE | 4.0 | 1 | 5.89 |
| CHEMBL64391 | ITRACONAZOLE | 4.0 | 1 | 5.86 |
| CHEMBL954 | ENCLOMIPHENE | 3.0 | 1 | 5.86 |
| CHEMBL439 | SULFADIAZINE | 4.0 | 1 | 5.84 |
| CHEMBL422 | TRIFLUOPERAZINE | 4.0 | 1 | 5.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL172 | (S,R)-MEFLOQUINE | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL3039774 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL57004 | SITAMAQUINE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3392927 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL104 | CLOTRIMAZOLE | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3392933 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL808 | ECONAZOLE | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL564 | PROMAZINE | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL91 | MICONAZOLE | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL726 | FLUPHENAZINE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL809 | SERTRALINE | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL437765 | RIFAMYCIN | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL445 | NORTRIPTYLINE | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL1200438 | TIOCONAZOLE | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL534 | KETOTIFEN | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL487366 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL415087 | CLOPERASTINE | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL3392928 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL3392935 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL1200438 | TIOCONAZOLE | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL1448 | NICLOSAMIDE | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL629 | AMITRIPTYLINE | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL1113 | AMOXAPINE | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL1169388 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL932 | DIPYRIDAMOLE | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL415 | CLOMIPRAMINE | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL64391 | ITRACONAZOLE | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL954 | ENCLOMIPHENE | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL439 | SULFADIAZINE | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL422 | TRIFLUOPERAZINE | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL3392929 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL1366 | AURANOFIN | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL282121 | MEBEVERINE | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL267930 | SPIPERONE | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL294951 | PIZOTYLINE | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL729 | LOPINAVIR | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL570 | TRIFLUPROMAZINE | IC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL277535 | BIFONAZOLE | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL1434 | MINOCYCLINE | IC50 | = | 3580.0 | nM | 5.45 |
| CHEMBL242580 | CICLOPIROX OLAMINE | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL1292 | CLOFAZIMINE | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL18331 | PIRENPERONE | IC50 | = | 4350.0 | nM | 5.36 |
| CHEMBL436921 | — | IC50 | = | 4480.0 | nM | 5.35 |
| CHEMBL660 | AMANTADINE | IC50 | = | 5670.0 | nM | 5.25 |
| CHEMBL5483011 | INDINAVIR | IC50 | = | 6030.0 | nM | 5.22 |
| CHEMBL1592316 | — | IC50 | = | 6520.0 | nM | 5.19 |
| CHEMBL3392932 | — | IC50 | = | 7080.0 | nM | 5.15 |
| CHEMBL408 | TROGLITAZONE | IC50 | = | 7270.0 | nM | 5.14 |