Assay Detail
ADMET
CHEMBL4028921
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to 20 mins by membrane vesicle transport assay
629
Total Activities
629
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 629 | 4.69 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL595 | PIOGLITAZONE | 4.0 | 1 | 6.40 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 6.30 |
| CHEMBL2103735 | CETRORELIX ACETATE | 4.0 | 1 | 5.83 |
| CHEMBL223643 | VALINOMYCIN | — | 1 | 5.81 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 5.76 |
| CHEMBL1908360 | EVEROLIMUS | 4.0 | 1 | 5.70 |
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 5.70 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 5.57 |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 5.55 |
| CHEMBL21333 | PRANLUKAST | 4.0 | 1 | 5.53 |
| CHEMBL408 | TROGLITAZONE | 4.0 | 1 | 5.52 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 5.47 |
| CHEMBL15177 | MK-571 | — | 1 | 5.45 |
| CHEMBL932 | DIPYRIDAMOLE | 4.0 | 1 | 5.40 |
| CHEMBL1200692 | OLMESARTAN MEDOXOMIL | 4.0 | 1 | 5.33 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 5.31 |
| CHEMBL472 | GLYBURIDE | 4.0 | 1 | 5.30 |
| CHEMBL1136 | TELITHROMYCIN | 4.0 | 1 | 5.30 |
| CHEMBL623 | NEFAZODONE | 4.0 | 1 | 5.21 |
| CHEMBL1076241 | — | — | 1 | 5.19 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | 4.0 | 1 | 5.14 |
| CHEMBL1513 | IRBESARTAN | 4.0 | 1 | 5.14 |
| CHEMBL1569487 | LORNOXICAM | 3.0 | 1 | 5.12 |
| CHEMBL1484 | NICARDIPINE | 4.0 | 1 | 5.10 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 5.10 |
| CHEMBL429023 | ROTENONE | — | 1 | 5.10 |
| CHEMBL1397 | POSACONAZOLE | 4.0 | 1 | 5.09 |
| CHEMBL772 | RESERPINE | 4.0 | 1 | 5.08 |
| CHEMBL995 | LOSARTAN POTASSIUM | 4.0 | 1 | 5.07 |
| CHEMBL1200480 | OCTREOTIDE ACETATE | 4.0 | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL595 | PIOGLITAZONE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2103735 | CETRORELIX ACETATE | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL223643 | VALINOMYCIN | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL163 | RITONAVIR | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL1908360 | EVEROLIMUS | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 2690.0 | nM | 5.57 |
| CHEMBL121 | ROSIGLITAZONE | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL21333 | PRANLUKAST | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL408 | TROGLITAZONE | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL15177 | MK-571 | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL932 | DIPYRIDAMOLE | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1200692 | OLMESARTAN MEDOXOMIL | IC50 | = | 4730.0 | nM | 5.33 |
| CHEMBL114 | SAQUINAVIR | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL1136 | TELITHROMYCIN | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL472 | GLYBURIDE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL623 | NEFAZODONE | IC50 | = | 6110.0 | nM | 5.21 |
| CHEMBL1076241 | — | IC50 | = | 6490.0 | nM | 5.19 |
| CHEMBL1513 | IRBESARTAN | IC50 | = | 7310.0 | nM | 5.14 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | IC50 | = | 7180.0 | nM | 5.14 |
| CHEMBL1569487 | LORNOXICAM | IC50 | = | 7560.0 | nM | 5.12 |
| CHEMBL1484 | NICARDIPINE | IC50 | = | 7870.0 | nM | 5.10 |
| CHEMBL429023 | ROTENONE | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL1397 | POSACONAZOLE | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL772 | RESERPINE | IC50 | = | 8350.0 | nM | 5.08 |
| CHEMBL995 | LOSARTAN POTASSIUM | IC50 | = | 8530.0 | nM | 5.07 |
| CHEMBL1200480 | OCTREOTIDE ACETATE | IC50 | = | 9340.0 | nM | 5.03 |
| CHEMBL1555126 | LANOCONAZOLE | IC50 | = | 9650.0 | nM | 5.01 |
| CHEMBL1660 | RIFAPENTINE | IC50 | = | 9910.0 | nM | 5.00 |
| CHEMBL1200686 | PIMECROLIMUS | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL374975 | FUSIDIC ACID | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL344159 | TOLVAPTAN | IC50 | = | 9990.0 | nM | 5.00 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL939 | GEFITINIB | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL603 | ZAFIRLUKAST | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL589973 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL383634 | GLIQUIDONE | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL584 | NELFINAVIR | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL998 | LORATADINE | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL282724 | SITAXENTAN | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL1051 | LATANOPROST | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL1200476 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL393220 | ATORVASTATIN CALCIUM | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1292 | CLOFAZIMINE | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL428496 | WORTMANNIN | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL691 | ETHINYL ESTRADIOL | IC50 | = | 14000.0 | nM | 4.85 |