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Compound Detail

CHEMBL1569487

LORNOXICAM
🧪 Phase III
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🧪 Phase III
CN1C(C(=O)Nc2ccccn2)=C(O)c2sc(Cl)cc2S1(=O)=O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1569487
Name LORNOXICAM
Phase Phase III
Structure Type MOL
InChI Key WLHQHAUOOXYABV-UHFFFAOYSA-N
Therapeutic ✓ Yes

Known Names

CTX Lorcam Lornoxicam NSC-759620 RO 13-9297 RO-13-9297 RO-139297 Xefo
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
20
Publications
8
Known Names
4
Indications
1
Mechanisms

Molecular Properties

371.8
MW (Da)
2.30
ALogP
6
HBA
2
HBD
99.6
PSA (Ų)
0.84
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral

Flags

Natural Product
USAN Stem -icam
USAN Year 1993

Extended Properties

Molecular Formula C13H10ClN3O4S2
MW 371.83
Aromatic Rings 2
Heavy Atoms 23
NP-Likeness -1.42

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Cyclooxygenase inhibitor INHIBITOR Cyclooxygenase ✓ ✓

Indications

Rheumatic Diseases Pain Alzheimer Disease Migraine Disorders

ATC Classification

M01AC05
lornoxicam
Level 1: MUSCULO-SKELETAL SYSTEM
Level 2: ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS

Activity Summary

IC50 1 meas. best 5.12

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Bile salt export pump
CHEMBL6020
 IC50 5.12 5.12 7560.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Bile salt export pump IC50 = 7560.0 nM 5.12 Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as... 23956101

Literature References

PubMed DOI Target Context # Activities
- 10.6019/CHEMBL3885861 Rattus norvegicus 1437
37468498 10.1038/s41467-023-40064-9 Bile acid receptor 4
31995375 10.1021/acs.jmedchem.0c00046 Albumin 4
20014752 10.1021/tx900326k Hepatotoxicity 3
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 3
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2A 3
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 1A 3
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2B 3
37468498 10.1038/s41467-023-40064-9 Glucocorticoid receptor 3
37468498 10.1038/s41467-023-40064-9 Gamma-aminobutyric acid receptor subunit alpha-1 2
37468498 10.1038/s41467-023-40064-9 Retinoic acid receptor beta 2
37468498 10.1038/s41467-023-40064-9 Oxysterols receptor LXR-alpha 2
37468498 10.1038/s41467-023-40064-9 Oxysterols receptor LXR-beta 2
37468498 10.1038/s41467-023-40064-9 Nuclear receptor subfamily 1 group I member 2 2
37468498 10.1038/s41467-023-40064-9 Peroxisome proliferator-activated receptor alpha 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
37468498 10.1038/s41467-023-40064-9 Retinoic acid receptor gamma 2
37468498 10.1038/s41467-023-40064-9 Retinoic acid receptor alpha 2
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M2 2

Data from ChEMBL 36 via Core Engine