Compound Detail
CHEMBL374975
FUSIDIC ACID 🧪 Phase III
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🧪 Phase III
CC(=O)O[C@H]1C[C@@]2(C)[C@@H](C[C@@H](O)[C@H]3[C@@]4(C)CC[C@@H](O)[C@@H](C)[C@@H]4CC[C@@]32C)/C1=C(\CCC=C(C)C)C(=O)O
Basic Information
| ChEMBL ID | CHEMBL374975 |
| Name | FUSIDIC ACID |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | IECPWNUMDGFDKC-MZJAQBGESA-N |
| Therapeutic | ✓ Yes |
10
Targets
23
Activities
4
Assay Types
3
PK Parameters
20
Publications
13
Known Names
6
Indications
1
Mechanisms
Molecular Properties
516.7
MW (Da)
5.67
ALogP
5
HBA
3
HBD
104.1
PSA (Ų)
0.25
QED
2
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Elongation factor G inhibitor | INHIBITOR | Elongation factor G | ✓ | ✓ |
Indications
Bacterial Infections Eye Infections Carcinoma, Non-Small-Cell Lung Keloid Infections Skin Diseases
ATC Classification
D06AX01
fusidic acid
Level 1: DERMATOLOGICALS
Level 2: ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
D09AA02
fusidic acid
Level 1: DERMATOLOGICALS
Level 2: MEDICATED DRESSINGS
J01XC01
fusidic acid
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIBACTERIALS FOR SYSTEMIC USE
S01AA13
fusidic acid
Level 1: SENSORY ORGANS
Level 2: OPHTHALMOLOGICALS
Activity Summary
IC50 16 meas. best 5.16
Ki 5 meas. best 5.66
EC50 1 meas. best 5.07
Kd 1 meas. best 4.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Bile salt export pump CHEMBL2073674 | Ki | 5.66 | 5.66 | 2200.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 5.27 | 5.27 | 5400.0 | 1 |
| ATP-binding cassette sub-family C member 2 CHEMBL2073676 | Ki | 5.26 | 5.09 | 5500.0 | 3 |
| Toxoplasma gondii CHEMBL612888 | IC50 | 5.16 | 5.16 | 7000.0 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | EC50 | 5.07 | 5.07 | 8600.0 | 1 |
| Bile salt export pump CHEMBL6020 | IC50 | 5.0 | 4.98 | 10100.0 | 3 |
| Albumin CHEMBL3253 | Kd | 4.92 | 4.92 | 12000.0 | 1 |
| Bile salt export pump CHEMBL2073674 | IC50 | 4.76 | 4.76 | 17400.0 | 1 |
| Plasmodium falciparum CHEMBL364 | IC50 | 4.72 | 4.3243 | 19000.0 | 7 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 CHEMBL5393 | IC50 | 4.28 | 4.28 | 52000.0 | 1 |
| RAW264.7 CHEMBL612557 | IC50 | 4.21 | 4.21 | 61260.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 3304129.87 | ng.hr.mL-1 | Homo sapiens |
| Cmax | 58058.52 | nM | Homo sapiens |
| Fu | 0.05 | - | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine