Assay Detail
Functional
CHEMBL1663051
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Antiviral activity against JC polyomavirus M1/SVEdelta infected in human SVG-A cells assessed as inhibition of viral replication after 3 days
19
Total Activities
18
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | JC polyomavirus |
| Cell Type | SVG-A |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification and characterization of mefloquine efficacy against JC virus in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 5.04 | 5.57 |
| IC50 | 1 | 5.41 | 5.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411329 | (R,S)-MEFLOQUINE | — | 1 | 5.57 |
| CHEMBL416956 | MEFLOQUINE | 4.0 | 2 | 5.41 |
| CHEMBL547 | ISOTRETINOIN | 4.0 | 1 | 5.36 |
| CHEMBL172 | (S,R)-MEFLOQUINE | — | 1 | 5.35 |
| CHEMBL1222498 | PROPANIL | — | 1 | 5.11 |
| CHEMBL1034 | DICLOFENAC SODIUM | 4.0 | 1 | 5.08 |
| CHEMBL1697 | DILTIAZEM HYDROCHLORIDE | 4.0 | 1 | 5.07 |
| CHEMBL374975 | FUSIDIC ACID | 3.0 | 1 | 5.07 |
| CHEMBL1559 | MICONAZOLE NITRATE | 4.0 | 1 | 5.07 |
| CHEMBL23588 | FLUFENAMIC ACID | 2.0 | 1 | 4.96 |
| CHEMBL686 | MEFENAMIC ACID | 4.0 | 1 | 4.96 |
| CHEMBL1652147 | DEHYDROABIETAMIDE | — | 1 | 4.89 |
| CHEMBL1733447 | FLUNIXIN MEGLUMINE | -1.0 | 1 | 4.84 |
| CHEMBL367741 | DIFFRACTAIC ACID | — | 1 | 4.84 |
| CHEMBL12014 | HARMAN | — | 1 | 4.84 |
| CHEMBL121626 | TOLFENAMIC ACID | 2.0 | 1 | 4.82 |
| CHEMBL186784 | XANTHONE | — | 1 | 4.78 |
| CHEMBL1591080 | METHOXYVONE | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411329 | (R,S)-MEFLOQUINE | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL416956 | MEFLOQUINE | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL547 | ISOTRETINOIN | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL172 | (S,R)-MEFLOQUINE | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1222498 | PROPANIL | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL1034 | DICLOFENAC SODIUM | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL1559 | MICONAZOLE NITRATE | EC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL374975 | FUSIDIC ACID | EC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL1697 | DILTIAZEM HYDROCHLORIDE | EC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL686 | MEFENAMIC ACID | EC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL23588 | FLUFENAMIC ACID | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1652147 | DEHYDROABIETAMIDE | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1733447 | FLUNIXIN MEGLUMINE | EC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL367741 | DIFFRACTAIC ACID | EC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL12014 | HARMAN | EC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL121626 | TOLFENAMIC ACID | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL186784 | XANTHONE | EC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL1591080 | METHOXYVONE | EC50 | = | 17200.0 | nM | 4.76 |