Compound Detail
CHEMBL416956
MEFLOQUINE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL416956 |
| Name | MEFLOQUINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | XEEQGYMUWCZPDN-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
18
Targets
236
Activities
2
Assay Types
4
PK Parameters
20
Publications
8
Known Names
9
Indications
Molecular Properties
378.3
MW (Da)
4.45
ALogP
3
HBA
2
HBD
45.1
PSA (Ų)
0.76
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1989 |
| Availability | Prescription |
| Chirality | Racemic |
Indications
Malaria Malaria, Falciparum Schistosomiasis haematobia Pneumonia, Viral Respiratory Insufficiency Severe Acute Respiratory Syndrome Glioblastoma Gliosarcoma Leukoencephalopathy, Progressive Multifocal
ATC Classification
P01BC02
mefloquine
Level 1: ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
Level 2: ANTIPROTOZOALS
Activity Summary
IC50 217 meas. best 9.51
EC50 19 meas. best 8.31
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 9.51 | 7.7532 | 0.3 | 162 |
| Plasmodium falciparum CHEMBL364 | EC50 | 8.31 | 7.5871 | 4.9 | 14 |
| Plasmodium vivax CHEMBL613013 | IC50 | 8.19 | 7.8383 | 6.4 | 18 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 7.62 | 5.675 | 23.8 | 6 |
| Plasmodium malariae CHEMBL613257 | IC50 | 7.43 | 7.38 | 36.8 | 2 |
| Glycine receptor subunit alpha-1 CHEMBL5845 | EC50 | 5.6 | 5.6 | 2500.0 | 1 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | IC50 | 5.58 | 5.335 | 2600.0 | 4 |
| Unchecked CHEMBL612545 | IC50 | 5.54 | 4.795 | 2900.0 | 4 |
| NON-PROTEIN TARGET CHEMBL3879801 | EC50 | 5.4 | 5.4 | 4000.0 | 1 |
| SARS-CoV-2 CHEMBL4303835 | IC50 | 5.36 | 5.36 | 4330.0 | 1 |
| L6 CHEMBL614793 | IC50 | 5.32 | 5.035 | 4760.0 | 4 |
| Monkeypox virus CHEMBL613120 | EC50 | 5.29 | 5.29 | 5190.0 | 1 |
| RAW264.7 CHEMBL612557 | IC50 | 5.19 | 5.19 | 6500.0 | 1 |
| Leishmania infantum CHEMBL612848 | IC50 | 5.16 | 5.16 | 7000.0 | 1 |
| LoVo CHEMBL614721 | IC50 | 5.1 | 5.1 | 7900.0 | 1 |
| MCF7 CHEMBL387 | IC50 | 4.97 | 4.97 | 10600.0 | 1 |
| Vero CHEMBL391 | IC50 | 4.96 | 4.96 | 11000.0 | 2 |
| Protein kinase Pfmrk CHEMBL4090 | IC50 | 4.92 | 4.92 | 12000.0 | 1 |
| Leishmania major CHEMBL612879 | EC50 | 4.9 | 4.88 | 12480.0 | 2 |
| DU-145 CHEMBL613508 | IC50 | 4.84 | 4.84 | 14400.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| Ka | 0.1 | 10^5/M | - |
| Ka | 8.7 | 10^5/M | Homo sapiens |
| Ka | 8.0 | 10^4/M | Homo sapiens |
| T1/2 | 1.0 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine