Assay Detail
Functional
CHEMBL760062
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Intrinsic equimolar activity against Plasmodium falciparum D6 (Sierra Leone) relative to QHS
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Arteether, a new antimalarial drug: synthesis and antimalarial properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.74 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416956 | MEFLOQUINE | 4.0 | 1 | 9.51 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 9.01 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 9.00 |
| CHEMBL566534 | ARTEMETHER | 4.0 | 1 | 8.63 |
| CHEMBL469416 | ALPHA-ARTEETHER | — | 1 | 8.60 |
| CHEMBL301267 | ARTEMOTIL | 2.0 | 1 | 8.59 |
| CHEMBL207675 | SODIUM ARESUNATE | — | 1 | 8.32 |
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 8.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 0.97 | nM | 9.01 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL566534 | ARTEMETHER | IC50 | = | 2.34 | nM | 8.63 |
| CHEMBL469416 | ALPHA-ARTEETHER | IC50 | = | 2.52 | nM | 8.60 |
| CHEMBL301267 | ARTEMOTIL | IC50 | = | 2.58 | nM | 8.59 |
| CHEMBL207675 | SODIUM ARESUNATE | IC50 | = | 4.83 | nM | 8.32 |
| CHEMBL307261 | ARTENIMOL | IC50 | = | 5.75 | nM | 8.24 |