Assay Detail
Functional
CHEMBL950579
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Antimalarial activity against chloroquine-resistant, mefloquine-sensitive Plasmodium falciparum RCS
21
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Mixed tetraoxanes containing the acetone subunit as antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC90 | 11 | - | - |
| IC50 | 10 | 7.96 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL501647 | — | — | 2 | 8.72 |
| CHEMBL416956 | MEFLOQUINE | 4.0 | 2 | 8.63 |
| CHEMBL510410 | — | — | 2 | 8.15 |
| CHEMBL507515 | — | — | 2 | 8.14 |
| CHEMBL509229 | — | — | 2 | 7.94 |
| CHEMBL510548 | — | — | 2 | 7.41 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 2 | 6.72 |
| CHEMBL505437 | — | — | 2 | - |
| CHEMBL499752 | — | — | 2 | - |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | - |
| CHEMBL450192 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL501647 | — | IC50 | = | 1.89 | nM | 8.72 |
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 2.33 | nM | 8.63 |
| CHEMBL510410 | — | IC50 | = | 7.03 | nM | 8.15 |
| CHEMBL507515 | — | IC50 | = | 7.19 | nM | 8.14 |
| CHEMBL509229 | — | IC50 | = | 11.55 | nM | 7.94 |
| CHEMBL510548 | — | IC50 | = | 38.7 | nM | 7.41 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 192.45 | nM | 6.72 |
| CHEMBL505437 | — | IC90 | - | — | - | |
| CHEMBL499752 | — | IC50 | - | — | - | |
| CHEMBL499752 | — | IC90 | - | — | - | |
| CHEMBL509229 | — | IC90 | = | 22.26 | nM | - |
| CHEMBL76 | CHLOROQUINE | IC90 | = | 397.09 | nM | - |
| CHEMBL416956 | MEFLOQUINE | IC90 | = | 5.0 | nM | - |
| CHEMBL505437 | — | IC50 | - | — | - | |
| CHEMBL510548 | — | IC90 | = | 167.7 | nM | - |
| CHEMBL510410 | — | IC90 | = | 19.49 | nM | - |
| CHEMBL507515 | — | IC90 | = | 14.0 | nM | - |
| CHEMBL501647 | — | IC90 | = | 4.45 | nM | - |
| CHEMBL450192 | — | IC50 | - | — | - | |
| CHEMBL450192 | — | IC90 | - | — | - | |
| CHEMBL269671 | ARTEMISININ | IC90 | = | 13.04 | nM | - |