Assay Detail
Functional
CHEMBL2343469
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and structure-activity relationships of pyrrolone antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.66 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416956 | MEFLOQUINE | 4.0 | 1 | 8.31 |
| CHEMBL600928 | — | — | 1 | 8.08 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416956 | MEFLOQUINE | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL600928 | — | EC50 | = | 8.4 | nM | 8.08 |
| CHEMBL76 | CHLOROQUINE | EC50 | = | 260.0 | nM | 6.58 |