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Assay Detail

CHEMBL765668

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibitory activity against chloroquine-resistant Plasmodium falciparum W2 Indochina
46
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Expert

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Mixed steroidal 1,2,4,5-tetraoxanes: antimalarial and antimycobacterial activity.
Solaja BA, Terzić N, Pocsfalvi G, Gerena L, Tinant B, Opsenica D, Milhous WK.
J Med Chem (2002) 45 : 3331 -3336
PubMed 12139444 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 46 7.92 9.24

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3084853 2 9.24
CHEMBL3084848 2 9.01
CHEMBL301267 ARTEMOTIL 2.0 1 8.85
CHEMBL1208264 ARTELINIC ACID 1 8.48
CHEMBL3084849 2 8.44
CHEMBL3084842 2 8.42
CHEMBL3084843 2 8.41
CHEMBL3084851 2 8.35
CHEMBL3138391 1 8.32
CHEMBL416956 MEFLOQUINE 4.0 1 8.30
CHEMBL3349212 2 8.30
CHEMBL3084840 2 8.21
CHEMBL3138368 1 8.17
CHEMBL3084845 1 8.16
CHEMBL269671 ARTEMISININ 3.0 1 8.14
CHEMBL3084857 2 8.14
CHEMBL3084854 1 8.03
CHEMBL3084852 2 8.02
CHEMBL3084846 1 8.00
CHEMBL3084841 2 7.97
CHEMBL3138246 1 7.97
CHEMBL3084850 1 7.95
CHEMBL3084844 1 7.81
CHEMBL3084477 2 7.81
CHEMBL3138244 1 7.77
CHEMBL3138243 1 7.72
CHEMBL3138242 1 7.70
CHEMBL3349211 2 7.56
CHEMBL3138256 1 7.56
CHEMBL3084856 1 7.43

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3084853 IC50 = 0.58 nM 9.24
CHEMBL3084848 IC50 = 0.98 nM 9.01
CHEMBL301267 ARTEMOTIL IC50 = 1.4 nM 8.85
CHEMBL1208264 ARTELINIC ACID IC50 = 3.3 nM 8.48
CHEMBL3084849 IC50 = 3.61 nM 8.44
CHEMBL3084842 IC50 = 3.82 nM 8.42
CHEMBL3084843 IC50 = 3.93 nM 8.41
CHEMBL3084851 IC50 = 4.51 nM 8.35
CHEMBL3138391 IC50 = 4.74 nM 8.32
CHEMBL416956 MEFLOQUINE IC50 = 5.02 nM 8.30
CHEMBL3349212 IC50 = 5.05 nM 8.30
CHEMBL3084840 IC50 = 6.15 nM 8.21
CHEMBL3138368 IC50 = 6.8 nM 8.17
CHEMBL3084845 IC50 = 6.97 nM 8.16
CHEMBL3084857 IC50 = 7.26 nM 8.14
CHEMBL269671 ARTEMISININ IC50 = 7.3 nM 8.14
CHEMBL3084840 IC50 = 7.82 nM 8.11
CHEMBL3084854 IC50 = 9.29 nM 8.03
CHEMBL3084852 IC50 = 9.56 nM 8.02
CHEMBL3084843 IC50 = 9.93 nM 8.00
CHEMBL3084846 IC50 = 10.02 nM 8.00
CHEMBL3084841 IC50 = 10.71 nM 7.97
CHEMBL3138246 IC50 = 10.77 nM 7.97
CHEMBL3084850 IC50 = 11.12 nM 7.95
CHEMBL3084849 IC50 = 11.87 nM 7.93
CHEMBL3084841 IC50 = 12.52 nM 7.90
CHEMBL3349212 IC50 = 13.16 nM 7.88
CHEMBL3084853 IC50 = 14.1 nM 7.85
CHEMBL3084857 IC50 = 14.43 nM 7.84
CHEMBL3084477 IC50 = 15.46 nM 7.81
CHEMBL3084844 IC50 = 15.64 nM 7.81
CHEMBL3138244 IC50 = 16.96 nM 7.77
CHEMBL3084848 IC50 = 17.74 nM 7.75
CHEMBL3084852 IC50 = 18.07 nM 7.74
CHEMBL3138243 IC50 = 19.22 nM 7.72
CHEMBL3138242 IC50 = 20.0 nM 7.70
CHEMBL3349211 IC50 = 27.77 nM 7.56
CHEMBL3138256 IC50 = 27.67 nM 7.56
CHEMBL3084477 IC50 = 28.31 nM 7.55
CHEMBL3084856 IC50 = 37.51 nM 7.43
CHEMBL3349211 IC50 = 52.73 nM 7.28
CHEMBL3084847 IC50 = 73.24 nM 7.13
CHEMBL3084842 IC50 = 83.01 nM 7.08
CHEMBL3084851 IC50 = 122.68 nM 6.91
CHEMBL76 CHLOROQUINE IC50 = 185.38 nM 6.73
CHEMBL3084855 IC50 = 357.08 nM 6.45