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Assay Detail

CHEMBL895774

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Functional
Antimalarial activity against Plasmodium falciparum W2
ChEMBL ↗
60
Total Activities
22
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364) ↗
Type ORGANISM
Organism Plasmodium falciparum

Publication

Deoxycholic acid-derived tetraoxane antimalarials and antiproliferatives(1).
Terzić N, Opsenica D, Milić D, Tinant B, Smith KS, Milhous WK, Solaja BA.
J Med Chem (2007) 50 : 5118 -5127
PubMed 17887664 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 30 7.47 8.51
IC90 30 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL416956 MEFLOQUINE 4.0 2 8.51
CHEMBL269671 ARTEMISININ 3.0 2 8.17
CHEMBL243890 — — 4 8.11
CHEMBL397724 — — 4 8.00
CHEMBL269067 — — 2 7.95
CHEMBL389098 — — 4 7.92
CHEMBL388254 — — 2 7.84
CHEMBL410156 — — 4 7.78
CHEMBL443226 — — 4 7.77
CHEMBL245160 — — 4 7.73
CHEMBL243597 — — 2 7.72
CHEMBL410155 — — 4 7.64
CHEMBL388890 — — 4 7.47
CHEMBL244417 — — 2 7.39
CHEMBL245154 — — 2 7.26
CHEMBL397286 — — 2 7.09
CHEMBL396285 — — 2 7.03
CHEMBL244523 — — 2 6.98
CHEMBL243436 — — 2 6.95
CHEMBL243454 — — 2 6.82
CHEMBL3138356 — — 2 6.46
CHEMBL76 CHLOROQUINE 4.0 2 6.31

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL416956 MEFLOQUINE IC50 = 3.09 nM 8.51
CHEMBL269671 ARTEMISININ IC50 = 6.7 nM 8.17
CHEMBL243890 — IC50 = 7.86 nM 8.11
CHEMBL397724 — IC50 = 10.1 nM 8.00
CHEMBL269067 — IC50 = 11.24 nM 7.95
CHEMBL389098 — IC50 = 12.05 nM 7.92
CHEMBL388254 — IC50 = 14.49 nM 7.84
CHEMBL410156 — IC50 = 16.67 nM 7.78
CHEMBL443226 — IC50 = 16.83 nM 7.77
CHEMBL245160 — IC50 = 18.76 nM 7.73
CHEMBL243597 — IC50 = 19.08 nM 7.72
CHEMBL245160 — IC50 = 19.43 nM 7.71
CHEMBL410155 — IC50 = 23.1 nM 7.64
CHEMBL243890 — IC50 = 23.1 nM 7.64
CHEMBL397724 — IC50 = 33.83 nM 7.47
CHEMBL388890 — IC50 = 34.21 nM 7.47
CHEMBL388890 — IC50 = 38.3 nM 7.42
CHEMBL244417 — IC50 = 40.76 nM 7.39
CHEMBL389098 — IC50 = 42.24 nM 7.37
CHEMBL410156 — IC50 = 43.54 nM 7.36
CHEMBL410155 — IC50 = 50.82 nM 7.29
CHEMBL245154 — IC50 = 55.49 nM 7.26
CHEMBL397286 — IC50 = 81.62 nM 7.09
CHEMBL396285 — IC50 = 93.86 nM 7.03
CHEMBL244523 — IC50 = 104.87 nM 6.98
CHEMBL243436 — IC50 = 111.69 nM 6.95
CHEMBL443226 — IC50 = 135.93 nM 6.87
CHEMBL243454 — IC50 = 150.14 nM 6.82
CHEMBL3138356 — IC50 = 346.75 nM 6.46
CHEMBL76 CHLOROQUINE IC50 = 491.53 nM 6.31
CHEMBL244523 — IC90 = 276.13 nM -
CHEMBL397286 — IC90 = 195.48 nM -
CHEMBL243454 — IC90 = 168.75 nM -
CHEMBL245154 — IC90 = 78.62 nM -
CHEMBL3138356 — IC90 - — -
CHEMBL269067 — IC90 = 25.93 nM -
CHEMBL388254 — IC90 = 45.14 nM -
CHEMBL269671 ARTEMISININ IC90 = 11.5 nM -
CHEMBL243436 — IC90 = 170.27 nM -
CHEMBL244417 — IC90 = 110.94 nM -
CHEMBL389098 — IC90 = 89.66 nM -
CHEMBL245160 — IC90 = 118.0 nM -
CHEMBL397724 — IC90 = 53.7 nM -
CHEMBL388890 — IC90 = 80.3 nM -
CHEMBL443226 — IC90 = 155.03 nM -
CHEMBL389098 — IC90 = 84.75 nM -
CHEMBL76 CHLOROQUINE IC90 = 349.35 nM -
CHEMBL410155 — IC90 = 76.86 nM -
CHEMBL243890 — IC90 = 54.61 nM -
CHEMBL410156 — IC90 = 94.02 nM -