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Assay Detail

CHEMBL1775486

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Functional
Antimalarial activity against Plasmodium falciparum W2
30
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus.
Opsenica I, Burnett JC, Gussio R, Opsenica D, Todorović N, Lanteri CA, Sciotti RJ, Gettayacamin M, Basilico N, Taramelli D, Nuss JE, Wanner L, Panchal RG, Solaja BA, Bavari S.
J Med Chem (2011) 54 : 1157 -1169
PubMed 21265542 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC90 15 - -
IC50 15 7.68 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1773165 2 8.70
CHEMBL1773160 2 8.46
CHEMBL416956 MEFLOQUINE 4.0 2 8.31
CHEMBL1773164 2 8.26
CHEMBL1773073 2 8.21
CHEMBL269671 ARTEMISININ 3.0 2 8.17
CHEMBL1773163 2 8.16
CHEMBL1773161 2 8.11
CHEMBL1773162 2 8.09
CHEMBL1773159 2 8.06
CHEMBL1773158 2 8.04
CHEMBL1773157 2 6.45
CHEMBL76 CHLOROQUINE 4.0 2 6.34
CHEMBL1773156 2 6.06
CHEMBL1773155 2 5.77

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1773165 IC50 = 2.0 nM 8.70
CHEMBL1773160 IC50 = 3.48 nM 8.46
CHEMBL416956 MEFLOQUINE IC50 = 4.93 nM 8.31
CHEMBL1773164 IC50 = 5.5 nM 8.26
CHEMBL1773073 IC50 = 6.12 nM 8.21
CHEMBL269671 ARTEMISININ IC50 = 6.7 nM 8.17
CHEMBL1773163 IC50 = 6.98 nM 8.16
CHEMBL1773161 IC50 = 7.75 nM 8.11
CHEMBL1773162 IC50 = 8.11 nM 8.09
CHEMBL1773159 IC50 = 8.65 nM 8.06
CHEMBL1773158 IC50 = 9.19 nM 8.04
CHEMBL1773157 IC50 = 352.71 nM 6.45
CHEMBL76 CHLOROQUINE IC50 = 456.2 nM 6.34
CHEMBL1773156 IC50 = 871.25 nM 6.06
CHEMBL1773155 IC50 = 1701.59 nM 5.77
CHEMBL1773155 IC90 = 3262.4 nM -
CHEMBL1773156 IC90 = 1785.2 nM -
CHEMBL1773160 IC90 = 10.12 nM -
CHEMBL1773159 IC90 = 46.73 nM -
CHEMBL1773158 IC90 = 31.23 nM -
CHEMBL76 CHLOROQUINE IC90 = 697.97 nM -
CHEMBL1773163 IC90 = 22.5 nM -
CHEMBL1773162 IC90 = 28.0 nM -
CHEMBL1773161 IC90 = 25.37 nM -
CHEMBL416956 MEFLOQUINE IC90 = 15.25 nM -
CHEMBL1773157 IC90 = 708.66 nM -
CHEMBL269671 ARTEMISININ IC90 = 11.5 nM -
CHEMBL1773165 IC90 = 6.38 nM -
CHEMBL1773073 IC90 = 11.5 nM -
CHEMBL1773164 IC90 = 15.37 nM -