Assay Detail
Functional
CHEMBL945570
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Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum PFB Brazil by [3H]hypoxanthine uptake
10
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.71 | 8.70 |
| IC90 | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416956 | MEFLOQUINE | 4.0 | 2 | 8.70 |
| CHEMBL501860 | STRYCHNOGUCINE B | — | 2 | 6.70 |
| CHEMBL507761 | — | — | 2 | 6.37 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 2 | 6.27 |
| CHEMBL508603 | STRYCHNOGUCINE A | — | 2 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL501860 | STRYCHNOGUCINE B | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL507761 | — | IC50 | = | 431.0 | nM | 6.37 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL508603 | STRYCHNOGUCINE A | IC50 | = | 3199.0 | nM | 5.50 |
| CHEMBL508603 | STRYCHNOGUCINE A | IC90 | = | 9403.0 | nM | - |
| CHEMBL501860 | STRYCHNOGUCINE B | IC90 | = | 1150.0 | nM | - |
| CHEMBL507761 | — | IC90 | = | 1644.0 | nM | - |
| CHEMBL76 | CHLOROQUINE | IC90 | = | 1544.0 | nM | - |
| CHEMBL416956 | MEFLOQUINE | IC90 | = | 6.0 | nM | - |