Compound Detail
CHEMBL508603
STRYCHNOGUCINE A Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
C/C=C1/CN2[C@@H]([C@@H]3C(=O)N4c5ccccc5[C@@]56CCN7CC8=CCO[C@@H]3[C@@H]([C@H]45)[C@H]8C[C@H]76)C[C@@]34c5ccccc5N5C(=O)CC=C([C@H]1C[C@H]23)[C@H]54
Basic Information
| ChEMBL ID | CHEMBL508603 |
| Name | STRYCHNOGUCINE A |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PXWJNFJRUYWQOX-DSNAYJLUSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
650.8
MW (Da)
4.72
ALogP
5
HBA
0
HBD
56.3
PSA (Ų)
0.42
QED
1
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 5.64 | 5.4867 | 2310.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 2310.0 | nM | 5.64 | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum FCA ... | 11170658 |
| Plasmodium falciparum | IC50 | = | 3199.0 | nM | 5.5 | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum PFB ... | 11170658 |
| Plasmodium falciparum | IC50 | = | 4813.0 | nM | 5.32 | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum F32-... | 11170658 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11170658 | 10.1021/np000285t | Plasmodium falciparum | 7 |
Data from ChEMBL 36 via Core Engine