Assay Detail
Functional
CHEMBL945569
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Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum F32-Tanzania by [3H]hypoxanthine uptake
10
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.60 | 7.85 |
| IC90 | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 2 | 7.85 |
| CHEMBL416956 | MEFLOQUINE | 4.0 | 2 | 7.64 |
| CHEMBL501860 | STRYCHNOGUCINE B | — | 2 | 6.29 |
| CHEMBL507761 | — | — | 2 | 5.90 |
| CHEMBL508603 | STRYCHNOGUCINE A | — | 2 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL501860 | STRYCHNOGUCINE B | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL507761 | — | IC50 | = | 1263.0 | nM | 5.90 |
| CHEMBL508603 | STRYCHNOGUCINE A | IC50 | = | 4813.0 | nM | 5.32 |
| CHEMBL508603 | STRYCHNOGUCINE A | IC90 | = | 9543.0 | nM | - |
| CHEMBL501860 | STRYCHNOGUCINE B | IC90 | = | 3228.0 | nM | - |
| CHEMBL507761 | — | IC90 | = | 5349.0 | nM | - |
| CHEMBL76 | CHLOROQUINE | IC90 | = | 63.0 | nM | - |
| CHEMBL416956 | MEFLOQUINE | IC90 | = | 354.0 | nM | - |