Assay Detail

CHEMBL945567

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Functional

Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum FCA 20 Ghana by [3H]hypoxanthine uptake

ChEMBL ↗

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Target

Plasmodium falciparum (CHEMBL364) ↗

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Primary target Plasmodium falciparum

CHEMBL364

Anchored from Assay target.

Protein identity Plasmodium falciparum

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Plasmodium falciparum
Confidence	1 — Organism
Curated By	Autocuration

Target

Plasmodium falciparum (CHEMBL364) ↗

Type	ORGANISM
Organism	Plasmodium falciparum

Publication

Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.

Frédérich M, De Pauw M, Prosperi C, Tits M, Brandt V, Penelle J, Hayette M, DeMol P, Angenot L.
J Nat Prod (2001) 64 : 12 -16
PubMed 11170658 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	7	6.17	7.70
IC90	7	-	-

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL76	CHLOROQUINE	4.0	2	7.70
CHEMBL170	QUININE	4.0	2	6.57
CHEMBL501860	STRYCHNOGUCINE B	—	2	6.21
CHEMBL507761	—	—	2	6.07
CHEMBL524656	ISOSUNGUCINE	—	2	5.88
CHEMBL508603	STRYCHNOGUCINE A	—	2	5.64
CHEMBL501933	SUNGUCINE	—	2	5.11

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL76	CHLOROQUINE	IC50	=	20.0	nM	7.70
CHEMBL170	QUININE	IC50	=	269.0	nM	6.57
CHEMBL501860	STRYCHNOGUCINE B	IC50	=	617.0	nM	6.21
CHEMBL507761	—	IC50	=	847.0	nM	6.07
CHEMBL524656	ISOSUNGUCINE	IC50	=	1315.0	nM	5.88
CHEMBL508603	STRYCHNOGUCINE A	IC50	=	2310.0	nM	5.64
CHEMBL501933	SUNGUCINE	IC50	=	7816.0	nM	5.11
CHEMBL508603	STRYCHNOGUCINE A	IC90	=	6980.0	nM	-
CHEMBL501860	STRYCHNOGUCINE B	IC90	=	3785.0	nM	-
CHEMBL501933	SUNGUCINE	IC90	=	26256.0	nM	-
CHEMBL524656	ISOSUNGUCINE	IC90	=	7059.0	nM	-
CHEMBL507761	—	IC90	=	4348.0	nM	-
CHEMBL76	CHLOROQUINE	IC90	=	119.0	nM	-
CHEMBL170	QUININE	IC90	=	1913.0	nM	-