Assay Detail
Functional
CHEMBL1678152
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBCs by firefly luciferase reporter gene assay
94
Total Activities
94
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 94 | 6.60 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL577736 | TYROTHRICIN | 2.0 | 1 | 10.30 |
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 9.39 |
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 9.22 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 9.00 |
| CHEMBL554190 | QUINACRINE DIHYDROCHLORIDE | — | 1 | 9.00 |
| CHEMBL1255782 | EMETINE DIHYDROCHLORIDE HYDRATE | — | 1 | 9.00 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.70 |
| CHEMBL416956 | MEFLOQUINE | 4.0 | 1 | 8.68 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 8.48 |
| CHEMBL1256647 | — | — | 1 | 8.40 |
| CHEMBL1256788 | — | — | 1 | 8.30 |
| CHEMBL588619 | CINCHONINE | -1.0 | 1 | 8.30 |
| CHEMBL1673264 | — | — | 1 | 8.28 |
| CHEMBL438 | SULFAMERAZINE | 4.0 | 1 | 8.22 |
| CHEMBL599514 | — | — | 1 | 7.96 |
| CHEMBL581889 | — | — | 1 | 7.85 |
| CHEMBL585145 | — | — | 1 | 7.85 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.66 |
| CHEMBL599937 | — | — | 1 | 7.60 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | 4.0 | 1 | 7.52 |
| CHEMBL1673265 | — | — | 1 | 7.50 |
| CHEMBL1257106 | AMPEROZIDE HYDROCHLORIDE | — | 1 | 7.46 |
| CHEMBL1673240 | — | — | 1 | 7.44 |
| CHEMBL935 | — | — | 1 | 7.38 |
| CHEMBL3707183 | QUINIDINE SULFATE | 4.0 | 1 | 7.25 |
| CHEMBL464538 | — | — | 1 | 6.97 |
| CHEMBL1673241 | — | — | 1 | 6.96 |
| CHEMBL1673242 | — | — | 1 | 6.89 |
| CHEMBL587714 | 3',4' DICHLOROBENZAMIL | — | 1 | 6.84 |
| CHEMBL1673243 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL577736 | TYROTHRICIN | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL307261 | ARTENIMOL | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL90555 | VINCRISTINE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL554190 | QUINACRINE DIHYDROCHLORIDE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1255782 | EMETINE DIHYDROCHLORIDE HYDRATE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL361497 | ARTESUNATE | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL1256647 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1256788 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL588619 | CINCHONINE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1673264 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL438 | SULFAMERAZINE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL599514 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL581889 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL585145 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL599937 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1673265 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1257106 | AMPEROZIDE HYDROCHLORIDE | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1673240 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL935 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3707183 | QUINIDINE SULFATE | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL464538 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL1673241 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1673242 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL587714 | 3',4' DICHLOROBENZAMIL | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL1673243 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1256878 | BENZAMIL HYDROCHLORIDE | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL1348834 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL296419 | ASTEMIZOLE | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL1673244 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL2359966 | QUININE SULFATE | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1673245 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1673246 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3187985 | APOMORPHINE HYDROCHLORIDE | IC50 | = | 373.0 | nM | 6.43 |
| CHEMBL1671882 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1673247 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1673248 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1673255 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL2092874 | AMPEROZIDE DIHYDROCHLORIDE | IC50 | = | 443.0 | nM | 6.35 |
| CHEMBL1673256 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL1673257 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL1673258 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL1256180 | 5-(N-METHYL-N-ISOBUTYL)AMILORIDE | IC50 | = | 549.0 | nM | 6.26 |
| CHEMBL90 | HISTAMINE | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL1673249 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL1673250 | — | IC50 | = | 710.0 | nM | 6.15 |