Compound Detail
CHEMBL577736
TYROTHRICIN 🧪 Phase II
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🧪 Phase II
CC(C)C[C@@H]1NC(=O)[C@H](CCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)NC1=O
Basic Information
| ChEMBL ID | CHEMBL577736 |
| Name | TYROTHRICIN |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | NLJVXZFCYKWXLH-DXTIXLATSA-N |
| Therapeutic | ✓ Yes |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
13
Known Names
1
Indications
Molecular Properties
1228.5
MW (Da)
Drug Information
| Molecule Type | Protein |
| Chirality | Single Enantiomer |
Indications
Eye Infections
ATC Classification
D06AX08
tyrothricin
Level 1: DERMATOLOGICALS
Level 2: ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
R02AB02
tyrothricin
Level 1: RESPIRATORY SYSTEM
Level 2: THROAT PREPARATIONS
S01AA05
tyrothricin
Level 1: SENSORY ORGANS
Level 2: OPHTHALMOLOGICALS
Activity Summary
IC50 1 meas. best 10.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 10.3 | 10.3 | 0.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 0.05 | nM | 10.3 | Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBCs by fi... | 20547797 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19586775 | 10.1016/j.bmc.2009.06.029 | Listeria monocytogenes | 4 |
| 19586775 | 10.1016/j.bmc.2009.06.029 | Micrococcus luteus | 2 |
| 20547797 | 10.1128/aac.00431-10 | Plasmodium falciparum | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B1 | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B3 | 1 |
Data from ChEMBL 36 via Core Engine