Compound Detail
CHEMBL1673265
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Basic Information
| ChEMBL ID | CHEMBL1673265 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FKJZEITYFWCXNM-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
413.3
MW (Da)
3.65
ALogP
4
HBA
0
HBD
57.7
PSA (Ų)
0.77
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 7.5 | 7.14 | 32.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 32.0 | nM | 7.5 | Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBCs by fi... | 20547797 |
| Plasmodium falciparum | IC50 | = | 94.0 | nM | 7.03 | Antiplasmodial activity against multidrug-resistant Plasmodium falciparum TM90C2... | 20547797 |
| Plasmodium falciparum | IC50 | = | 130.0 | nM | 6.89 | Antiplasmodial activity against Plasmodium falciparum 3D7 by SYBR Green 1-based ... | 20547797 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20547797 | 10.1128/aac.00431-10 | Plasmodium falciparum | 3 |
Data from ChEMBL 36 via Core Engine