Assay Detail
Functional
CHEMBL1678155
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Antiplasmodial activity against multidrug-resistant Plasmodium falciparum TM90C2B by SYBR Green 1-based fluorescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.73 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1673264 | — | — | 1 | 7.51 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.29 |
| CHEMBL581889 | — | — | 1 | 7.14 |
| CHEMBL599514 | — | — | 1 | 7.13 |
| CHEMBL1673265 | — | — | 1 | 7.03 |
| CHEMBL599937 | — | — | 1 | 6.96 |
| CHEMBL600319 | — | — | 1 | 6.29 |
| CHEMBL1673266 | — | — | 1 | 6.28 |
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1673264 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL581889 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL599514 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL1673265 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL599937 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL600319 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL1673266 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 12000.0 | nM | 4.92 |