Assay Detail
Functional
CHEMBL950582
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Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum W2
28
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Mixed tetraoxanes containing the acetone subunit as antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.78 | 8.51 |
| IC90 | 14 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416956 | MEFLOQUINE | 4.0 | 2 | 8.51 |
| CHEMBL501647 | — | — | 2 | 8.30 |
| CHEMBL444498 | — | — | 2 | 8.22 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 2 | 8.17 |
| CHEMBL510717 | — | — | 2 | 8.03 |
| CHEMBL450192 | — | — | 2 | 8.01 |
| CHEMBL505437 | — | — | 2 | 7.93 |
| CHEMBL510410 | — | — | 2 | 7.79 |
| CHEMBL507515 | — | — | 2 | 7.76 |
| CHEMBL503659 | — | — | 2 | 7.74 |
| CHEMBL509229 | — | — | 2 | 7.74 |
| CHEMBL499752 | — | — | 2 | 7.44 |
| CHEMBL510548 | — | — | 2 | 6.81 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 2 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 3.09 | nM | 8.51 |
| CHEMBL501647 | — | IC50 | = | 5.02 | nM | 8.30 |
| CHEMBL444498 | — | IC50 | = | 5.98 | nM | 8.22 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL510717 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL450192 | — | IC50 | = | 9.79 | nM | 8.01 |
| CHEMBL505437 | — | IC50 | = | 11.67 | nM | 7.93 |
| CHEMBL510410 | — | IC50 | = | 16.36 | nM | 7.79 |
| CHEMBL507515 | — | IC50 | = | 17.29 | nM | 7.76 |
| CHEMBL503659 | — | IC50 | = | 18.14 | nM | 7.74 |
| CHEMBL509229 | — | IC50 | = | 18.14 | nM | 7.74 |
| CHEMBL499752 | — | IC50 | = | 36.04 | nM | 7.44 |
| CHEMBL510548 | — | IC50 | = | 153.31 | nM | 6.81 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 349.35 | nM | 6.46 |
| CHEMBL505437 | — | IC90 | = | 20.7 | nM | - |
| CHEMBL76 | CHLOROQUINE | IC90 | = | 491.53 | nM | - |
| CHEMBL416956 | MEFLOQUINE | IC90 | = | 8.41 | nM | - |
| CHEMBL269671 | ARTEMISININ | IC90 | = | 11.5 | nM | - |
| CHEMBL510548 | — | IC90 | = | 233.95 | nM | - |
| CHEMBL510410 | — | IC90 | = | 22.95 | nM | - |
| CHEMBL507515 | — | IC90 | = | 31.62 | nM | - |
| CHEMBL444498 | — | IC90 | - | — | - | |
| CHEMBL501647 | — | IC90 | = | 14.35 | nM | - |
| CHEMBL499752 | — | IC90 | = | 94.67 | nM | - |
| CHEMBL450192 | — | IC90 | = | 16.76 | nM | - |
| CHEMBL503659 | — | IC90 | = | 29.25 | nM | - |
| CHEMBL509229 | — | IC90 | = | 20.7 | nM | - |
| CHEMBL510717 | — | IC90 | - | — | - |