Assay Detail
Functional
CHEMBL931179
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Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum by [3H]hypoxanthine incorporation
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.10 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 8.64 |
| CHEMBL566534 | ARTEMETHER | 4.0 | 1 | 8.55 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.35 |
| CHEMBL416956 | MEFLOQUINE | 4.0 | 1 | 8.31 |
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | 4.0 | 1 | 8.27 |
| CHEMBL1630 | — | — | 1 | 8.02 |
| CHEMBL303933 | PIPERAQUINE | 3.0 | 1 | 7.84 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL566534 | ARTEMETHER | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 4.85 | nM | 8.31 |
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL1630 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL303933 | PIPERAQUINE | IC50 | = | 14.6 | nM | 7.84 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 155.0 | nM | 6.81 |