Assay Detail
Functional
CHEMBL930052
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Antimalarial activity against Plasmodium falciparum W2 in MSF assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and heme-binding correlation with antimalarial activity of 3,6-bis-(omega-N,N-diethylaminoamyloxy)-4,5-difluoroxanthone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.33 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416956 | MEFLOQUINE | 4.0 | 1 | 9.15 |
| CHEMBL170 | QUININE | 4.0 | 1 | 7.22 |
| CHEMBL272664 | — | — | 1 | 6.92 |
| CHEMBL558580 | — | — | 1 | 6.82 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL170 | QUININE | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL272664 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL558580 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 290.0 | nM | 6.54 |