Assay Detail
Functional
CHEMBL925911
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Antimalarial activity against Plasmodium falciparum W2
43
Total Activities
23
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Chemical stability of the peroxide bond enables diversified synthesis of potent tetraoxane antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.77 | 8.31 |
| IC90 | 20 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416956 | MEFLOQUINE | 4.0 | 2 | 8.31 |
| CHEMBL262595 | — | — | 2 | 8.22 |
| CHEMBL259647 | — | — | 2 | 8.21 |
| CHEMBL261290 | — | — | 2 | 8.20 |
| CHEMBL260275 | — | — | 2 | 8.18 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 2 | 8.17 |
| CHEMBL259648 | — | — | 2 | 8.12 |
| CHEMBL260401 | — | — | 2 | 8.11 |
| CHEMBL259649 | — | — | 2 | 8.09 |
| CHEMBL260595 | — | — | 2 | 8.01 |
| CHEMBL260466 | — | — | 2 | 8.01 |
| CHEMBL260359 | — | — | 2 | 7.96 |
| CHEMBL406838 | — | — | 2 | 7.93 |
| CHEMBL264440 | — | — | 1 | 7.77 |
| CHEMBL258800 | — | — | 2 | 7.73 |
| CHEMBL257183 | — | — | 1 | 7.72 |
| CHEMBL406866 | — | — | 2 | 7.70 |
| CHEMBL258873 | — | — | 2 | 7.66 |
| CHEMBL261769 | — | — | 2 | 7.39 |
| CHEMBL403719 | — | — | 2 | 6.96 |
| CHEMBL261770 | — | — | 2 | 6.38 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 2 | 6.21 |
| CHEMBL260276 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 4.89 | nM | 8.31 |
| CHEMBL262595 | — | IC50 | = | 6.07 | nM | 8.22 |
| CHEMBL259647 | — | IC50 | = | 6.17 | nM | 8.21 |
| CHEMBL261290 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL260275 | — | IC50 | = | 6.54 | nM | 8.18 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL259648 | — | IC50 | = | 7.54 | nM | 8.12 |
| CHEMBL260401 | — | IC50 | = | 7.79 | nM | 8.11 |
| CHEMBL259649 | — | IC50 | = | 8.19 | nM | 8.09 |
| CHEMBL260466 | — | IC50 | = | 9.77 | nM | 8.01 |
| CHEMBL260595 | — | IC50 | = | 9.72 | nM | 8.01 |
| CHEMBL260359 | — | IC50 | = | 11.1 | nM | 7.96 |
| CHEMBL406838 | — | IC50 | = | 11.61 | nM | 7.93 |
| CHEMBL264440 | — | IC50 | = | 16.96 | nM | 7.77 |
| CHEMBL258800 | — | IC50 | = | 18.51 | nM | 7.73 |
| CHEMBL257183 | — | IC50 | = | 19.22 | nM | 7.72 |
| CHEMBL406866 | — | IC50 | = | 20.16 | nM | 7.70 |
| CHEMBL258873 | — | IC50 | = | 21.98 | nM | 7.66 |
| CHEMBL261769 | — | IC50 | = | 40.41 | nM | 7.39 |
| CHEMBL403719 | — | IC50 | = | 108.88 | nM | 6.96 |
| CHEMBL261770 | — | IC50 | = | 413.18 | nM | 6.38 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 616.94 | nM | 6.21 |
| CHEMBL259649 | — | IC90 | = | 20.6 | nM | - |
| CHEMBL261769 | — | IC90 | = | 62.48 | nM | - |
| CHEMBL269671 | ARTEMISININ | IC90 | = | 11.5 | nM | - |
| CHEMBL76 | CHLOROQUINE | IC90 | = | 1019.71 | nM | - |
| CHEMBL416956 | MEFLOQUINE | IC90 | = | 9.45 | nM | - |
| CHEMBL261290 | — | IC90 | = | 21.6 | nM | - |
| CHEMBL258800 | — | IC90 | = | 65.44 | nM | - |
| CHEMBL260359 | — | IC90 | = | 26.85 | nM | - |
| CHEMBL260466 | — | IC90 | = | 24.21 | nM | - |
| CHEMBL406838 | — | IC90 | = | 26.34 | nM | - |
| CHEMBL403719 | — | IC90 | = | 297.96 | nM | - |
| CHEMBL260595 | — | IC90 | = | 17.87 | nM | - |
| CHEMBL259648 | — | IC90 | = | 22.91 | nM | - |
| CHEMBL259647 | — | IC90 | = | 17.68 | nM | - |
| CHEMBL260401 | — | IC90 | = | 16.0 | nM | - |
| CHEMBL262595 | — | IC90 | = | 11.04 | nM | - |
| CHEMBL260276 | — | IC50 | > | 499.41 | nM | - |
| CHEMBL406866 | — | IC90 | = | 40.36 | nM | - |
| CHEMBL258873 | — | IC90 | = | 44.54 | nM | - |
| CHEMBL261770 | — | IC90 | = | 519.94 | nM | - |
| CHEMBL260275 | — | IC90 | = | 11.57 | nM | - |