Compound Detail
CHEMBL1559
MICONAZOLE NITRATE 💊 Approved Drug
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💊 Approved Drug
5
Targets
8
Activities
2
Assay Types
0
PK Parameters
20
Publications
30
Known Names
2
Indications
1
Mechanisms
Molecular Properties
416.1
MW (Da)
6.45
ALogP
3
HBA
0
HBD
27.1
PSA (Ų)
0.46
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1974 |
| Availability | OTC |
| Chirality | Racemic |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Cytochrome P450 51 inhibitor | INHIBITOR | Lanosterol 14-alpha demethylase | ✓ | ✓ |
Indications
Candidiasis, Vulvovaginal Tinea Pedis
Activity Summary
EC50 5 meas. best 5.13
IC50 3 meas. best 6.08
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trypanosoma cruzi CHEMBL368 | IC50 | 6.08 | 6.08 | 826.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.55 | 5.55 | 2846.0 | 1 |
| Unchecked CHEMBL612545 | EC50 | 5.13 | 5.11 | 7450.0 | 2 |
| NON-PROTEIN TARGET CHEMBL3879801 | EC50 | 5.07 | 5.07 | 8600.0 | 1 |
| Protein RecA CHEMBL1741171 | EC50 | 5.02 | 5.02 | 9630.0 | 1 |
| Alkaline phosphatase, tissue-nonspecific isozyme CHEMBL5979 | EC50 | 4.15 | 4.15 | 70585.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Trypanosoma cruzi | IC50 | = | 826.0 | nM | 6.08 | Antitrypanosomal activity against amastigote stage of Trypanosoma cruzi infected... | 23927763 |
| Unchecked | IC50 | = | 2846.0 | nM | 5.55 | PUBCHEM_BIOASSAY: High Throughput Screen to Identify Inhibitors of Mycobacterium... | - |
| Unchecked | EC50 | = | 7450.0 | nM | 5.13 | PUBCHEM_BIOASSAY: Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7K ce... | - |
| Unchecked | EC50 | = | 8190.0 | nM | 5.09 | PUBCHEM_BIOASSAY: Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7 cel... | - |
| NON-PROTEIN TARGET | EC50 | = | 8600.0 | nM | 5.07 | Antiviral activity against JC polyomavirus M1/SVEdelta infected in human SVG-A c... | 19258267 |
| Protein RecA | EC50 | = | 9630.0 | nM | 5.02 | PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inh... | - |
| Alkaline phosphatase, tissue-nonspecific isozyme | EC50 | = | 70585.0 | nM | 4.15 | PUBCHEM_BIOASSAY: uHTS identification of compounds activating TNAP in the absenc... | - |
Literature References
Data from ChEMBL 36 via Core Engine