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Target Snapshot

CHEMBL5979 Target Snapshot

Alkaline phosphatase, tissue-nonspecific isozyme · SINGLE PROTEIN · Homo sapiens

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1,496Compounds
58Assays
6Approved Drugs
1,777.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P05186. Use UniProt P05186 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P05186 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Alkaline phosphatase, tissue-nonspecific isozyme as ChEMBL target CHEMBL5979, mapped to UniProt P05186. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Alkaline phosphatase, tissue-nonspecific isozyme
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL5979
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P05186
Alkaline phosphatase, tissue-nonspecific isozyme
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Alkaline phosphatase, tissue-nonspecific isozyme is the right protein anchor across sources, using UniProt P05186 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameAlkaline phosphatase, tissue-nonspecific isozyme
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP05186
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAlkaline phosphatase, tissue-nonspecific isozyme
UniProt AccessionP05186
Component TypeProtein
Sequence Length524 aa

Alkaline phosphatase, tissue-nonspecific isozyme

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Alkaline phosphatase, tissue-nonspecific isozyme, mapped to UniProt P05186. Sequence length is 524 aa.

Mapped IDP05186
Review nameAlkaline phosphatase, tissue-nonspecific isozyme
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

6
Approved
2
Phase II
Assay Mix

Activity Type Distribution

IC501,316.0
KI6.0
EC50455.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5748322 9.4 IC50 0.4 Preclinical
CHEMBL6001738 9.4 IC50 0.4 Preclinical
CHEMBL5777450 9.3 IC50 0.5 Preclinical
CHEMBL5836952 9.3 IC50 0.5 Preclinical
CHEMBL5862935 9.22 IC50 0.6 Preclinical
CHEMBL5870362 9.22 IC50 0.6 Preclinical
CHEMBL6028619 9.22 IC50 0.6 Preclinical
CHEMBL5935757 9.1 IC50 0.8 Preclinical
CHEMBL5864273 9.05 IC50 0.9 Preclinical
CHEMBL6016114 9.05 IC50 0.9 Preclinical
Distribution

pChEMBL Value Distribution

166
5.0
97
5.5
144
6.0
58
6.5
38
7.0
33
7.5
52
8.0
44
8.5
14
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

58
Total Assays
663
Tested Compounds
4
Assay Types
Binding — 50 assays, 663 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 31 491 5.5
assay format 11 105 8.2
cell-based format 8 67 5.6
Functional — 4 assays, 261 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 4 261 4.6
ADME — 3 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 3 0 —
Toxicity — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine