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Assay Detail

CHEMBL1794426

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2097, AID2223, AID489010, AID492950]
ChEMBL ↗
2123
Total Activities
2118
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category confirmatory
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Protein RecA (CHEMBL1741171) ↗
Type SINGLE PROTEIN
Organism Mycobacterium tuberculosis

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 2123 5.39 7.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1463659 — — 1 7.72
CHEMBL3195749 — — 1 7.68
CHEMBL601757 — — 1 7.68
CHEMBL1334062 — — 1 7.52
CHEMBL1370184 — — 1 7.50
CHEMBL1576509 — — 1 7.45
CHEMBL599924 — — 1 7.43
CHEMBL1364506 — — 1 7.37
CHEMBL1733474 — — 1 7.33
CHEMBL1510156 — — 1 7.33
CHEMBL1590201 — — 1 7.32
CHEMBL1600684 — — 1 7.32
CHEMBL1507162 — — 1 7.32
CHEMBL579318 — — 1 7.19
CHEMBL2003651 — — 1 7.18
CHEMBL1573331 — — 1 7.18
CHEMBL3197091 — — 1 7.16
CHEMBL1479483 — — 1 7.15
CHEMBL1329726 — — 1 7.14
CHEMBL1521758 — — 1 7.13
CHEMBL1601281 — — 1 7.13
CHEMBL36654 ROEMERINE — 1 7.10
CHEMBL1405964 — — 1 7.10
CHEMBL1384702 — — 1 7.08
CHEMBL1417929 — — 1 7.00
CHEMBL1489633 — — 1 6.98
CHEMBL1542693 — — 1 6.97
CHEMBL1583199 — — 1 6.96
CHEMBL3196451 — — 1 6.92
CHEMBL2000517 — — 1 6.91

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1463659 — EC50 = 19.1 nM 7.72
CHEMBL601757 — EC50 = 20.9 nM 7.68
CHEMBL3195749 — EC50 = 20.8 nM 7.68
CHEMBL1334062 — EC50 = 30.5 nM 7.52
CHEMBL1370184 — EC50 = 31.4 nM 7.50
CHEMBL1576509 — EC50 = 35.6 nM 7.45
CHEMBL599924 — EC50 = 36.8 nM 7.43
CHEMBL1364506 — EC50 = 43.0 nM 7.37
CHEMBL1733474 — EC50 = 46.6 nM 7.33
CHEMBL1510156 — EC50 = 47.0 nM 7.33
CHEMBL1590201 — EC50 = 47.9 nM 7.32
CHEMBL1507162 — EC50 = 47.8 nM 7.32
CHEMBL1600684 — EC50 = 48.2 nM 7.32
CHEMBL579318 — EC50 = 63.9 nM 7.19
CHEMBL1573331 — EC50 = 66.6 nM 7.18
CHEMBL2003651 — EC50 = 66.3 nM 7.18
CHEMBL3197091 — EC50 = 69.6 nM 7.16
CHEMBL1479483 — EC50 = 70.2 nM 7.15
CHEMBL1329726 — EC50 = 72.8 nM 7.14
CHEMBL1601281 — EC50 = 74.4 nM 7.13
CHEMBL1521758 — EC50 = 74.5 nM 7.13
CHEMBL36654 ROEMERINE EC50 = 79.7 nM 7.10
CHEMBL1405964 — EC50 = 80.1 nM 7.10
CHEMBL1384702 — EC50 = 82.5 nM 7.08
CHEMBL1417929 — EC50 = 101.0 nM 7.00
CHEMBL1489633 — EC50 = 104.0 nM 6.98
CHEMBL1542693 — EC50 = 108.0 nM 6.97
CHEMBL1583199 — EC50 = 109.0 nM 6.96
CHEMBL3196451 — EC50 = 119.0 nM 6.92
CHEMBL2000517 — EC50 = 123.0 nM 6.91
CHEMBL3195410 — EC50 = 124.0 nM 6.91
CHEMBL1479754 — EC50 = 132.0 nM 6.88
CHEMBL3191855 — EC50 = 141.0 nM 6.85
CHEMBL2095095 — EC50 = 143.0 nM 6.84
CHEMBL1307207 — EC50 = 146.0 nM 6.84
CHEMBL1718805 — EC50 = 152.0 nM 6.82
CHEMBL1454614 — EC50 = 150.0 nM 6.82
CHEMBL1383986 — EC50 = 152.0 nM 6.82
CHEMBL1452061 — EC50 = 155.0 nM 6.81
CHEMBL1471498 — EC50 = 160.0 nM 6.80
CHEMBL1734820 — EC50 = 158.0 nM 6.80
CHEMBL1559655 — EC50 = 159.0 nM 6.80
CHEMBL1508839 — EC50 = 175.0 nM 6.76
CHEMBL1395600 — EC50 = 178.0 nM 6.75
CHEMBL1411044 — EC50 = 178.0 nM 6.75
CHEMBL1567246 — EC50 = 183.0 nM 6.74
CHEMBL3192555 — EC50 = 185.0 nM 6.73
CHEMBL1706216 — EC50 = 187.0 nM 6.73
CHEMBL1563903 — EC50 = 189.0 nM 6.72
CHEMBL1992432 — EC50 = 191.0 nM 6.72