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Compound Detail

CHEMBL1417929

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O=C(NC1=C(NC2CCS(=O)(=O)C2)C(=O)c2ccccc2C1=O)c1ccccc1

Basic Information

ChEMBL ID CHEMBL1417929
Phase Preclinical
Structure Type MOL
InChI Key XXPFGRVEANGYDQ-UHFFFAOYSA-N
6
Targets
11
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

410.4
MW (Da)
1.48
ALogP
6
HBA
2
HBD
109.4
PSA (Ų)
0.79
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H18N2O5S
MW 410.45
Aromatic Rings 2
Heavy Atoms 29
NP-Likeness -1.01

Activity Summary

IC50 7 meas. best 5.68
EC50 4 meas. best 7.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Protein RecA
CHEMBL1741171
EC50 7.0 7.0 101.0 1
Apoptotic protease-activating factor 1
CHEMBL1795093
IC50 5.68 5.68 2100.0 1
Unchecked
CHEMBL612545
IC50 5.58 5.28 2640.0 3
BJ
CHEMBL614358
EC50 5.48 5.22 3278.0 2
Hexokinase HKDC1
CHEMBL1741200
IC50 5.29 5.245 5140.0 2
Unchecked
CHEMBL612545
EC50 4.83 4.83 14622.0 1
Tyrosyl-DNA phosphodiesterase 2
CHEMBL2169736
IC50 4.55 4.55 28332.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine