Assay Detail
Functional
CHEMBL1794383
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PUBCHEM_BIOASSAY: Dose response confirmation of uHTS hits for Apaf-1 in a Fluorescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID489030, AID492945]
476
Total Activities
474
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Category | confirmatory |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Apoptotic protease-activating factor 1 (CHEMBL1795093) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 476 | 4.93 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL601757 | — | — | 1 | 7.43 |
| CHEMBL599924 | — | — | 1 | 7.24 |
| CHEMBL1463659 | — | — | 1 | 7.10 |
| CHEMBL1583199 | — | — | 1 | 6.74 |
| CHEMBL1498509 | — | — | 1 | 6.50 |
| CHEMBL3189714 | — | — | 1 | 6.47 |
| CHEMBL3192555 | — | — | 1 | 6.39 |
| CHEMBL3191855 | — | — | 1 | 6.36 |
| CHEMBL1531324 | — | — | 1 | 6.35 |
| CHEMBL3196451 | — | — | 1 | 6.34 |
| CHEMBL51931 | 9,10-PHENANTHRENEQUINONE | — | 1 | 6.26 |
| CHEMBL1864348 | — | — | 1 | 6.15 |
| CHEMBL417727 | — | — | 1 | 6.12 |
| CHEMBL1522827 | — | — | 1 | 6.10 |
| CHEMBL1407514 | — | — | 1 | 6.10 |
| CHEMBL1432707 | — | — | 1 | 6.00 |
| CHEMBL3196591 | — | — | 1 | 5.99 |
| CHEMBL1888528 | — | — | 1 | 5.96 |
| CHEMBL1434767 | — | — | 1 | 5.91 |
| CHEMBL1454614 | — | — | 1 | 5.90 |
| CHEMBL1498652 | — | — | 1 | 5.88 |
| CHEMBL171632 | — | — | 1 | 5.86 |
| CHEMBL1996724 | — | — | 1 | 5.83 |
| CHEMBL1719244 | — | — | 1 | 5.82 |
| CHEMBL1999630 | — | — | 1 | 5.80 |
| CHEMBL1494979 | — | — | 1 | 5.78 |
| CHEMBL1430635 | — | — | 1 | 5.75 |
| CHEMBL3195749 | — | — | 1 | 5.74 |
| CHEMBL1898479 | — | — | 1 | 5.74 |
| CHEMBL2006503 | — | — | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL601757 | — | IC50 | = | 37.5 | nM | 7.43 |
| CHEMBL599924 | — | IC50 | = | 57.2 | nM | 7.24 |
| CHEMBL1463659 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL1583199 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL1498509 | — | IC50 | = | 316.0 | nM | 6.50 |
| CHEMBL3189714 | — | IC50 | = | 335.0 | nM | 6.47 |
| CHEMBL3192555 | — | IC50 | = | 411.0 | nM | 6.39 |
| CHEMBL3191855 | — | IC50 | = | 441.0 | nM | 6.36 |
| CHEMBL1531324 | — | IC50 | = | 443.0 | nM | 6.35 |
| CHEMBL3196451 | — | IC50 | = | 453.0 | nM | 6.34 |
| CHEMBL51931 | 9,10-PHENANTHRENEQUINONE | IC50 | = | 549.0 | nM | 6.26 |
| CHEMBL1864348 | — | IC50 | = | 707.0 | nM | 6.15 |
| CHEMBL417727 | — | IC50 | = | 768.0 | nM | 6.12 |
| CHEMBL1407514 | — | IC50 | = | 798.0 | nM | 6.10 |
| CHEMBL1522827 | — | IC50 | = | 797.0 | nM | 6.10 |
| CHEMBL1432707 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL3196591 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL1888528 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1434767 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL1454614 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL1498652 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL171632 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL1996724 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL1719244 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL1999630 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL1494979 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL1430635 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3195749 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL1898479 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL2006503 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL1987894 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL1380131 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL175434 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL1417929 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1328473 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL1395907 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL1409039 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL1593286 | — | IC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL299853 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL3193011 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL1707033 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1577193 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL1872457 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL3196108 | — | IC50 | = | 2630.0 | nM | 5.58 |
| CHEMBL1996376 | — | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL1458321 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1497070 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL3187596 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL1302524 | — | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL1968355 | — | IC50 | = | 2900.0 | nM | 5.54 |