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Compound Detail

CHEMBL1968355

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Cc1cc(C)nc(/N=c2/ssnc2Cl)c1

Basic Information

ChEMBL ID CHEMBL1968355
Phase Preclinical
Structure Type MOL
InChI Key AVDSFLMZEWGWOV-FMIVXFBMSA-N
6
Targets
9
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

257.8
MW (Da)
3.10
ALogP
5
HBA
0
HBD
38.1
PSA (Ų)
0.74
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C9H8ClN3S2
MW 257.77
Aromatic Rings 2
Heavy Atoms 15
NP-Likeness -1.06

Activity Summary

EC50 5 meas. best 6.43
IC50 4 meas. best 5.54

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
EC50 6.43 5.1 371.0 3
Apoptotic protease-activating factor 1
CHEMBL1795093
IC50 5.54 5.54 2900.0 1
Voltage-gated N-type calcium channel alpha-1B subunit/Amyloid beta A4 precursor protein-binding family A member 1
CHEMBL2097170
IC50 4.97 4.97 10600.0 1
Unchecked
CHEMBL612545
IC50 4.64 4.64 22800.0 1
Mannose-6-phosphate isomerase
CHEMBL2758
IC50 4.54 4.54 28848.0 1
Hexokinase-1
CHEMBL2688
EC50 4.4 4.4 39900.0 1
Hexokinase HKDC1
CHEMBL1741200
EC50 4.37 4.37 43100.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine