Assay Detail
Binding
CHEMBL3215006
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PubChem BioAssay. Epi Absorbance-based biochemical high throughput dose response assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2). (Class of assay: confirmatory)
222
Total Activities
221
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Category | confirmatory |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 222 | 4.86 | 6.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1325945 | — | — | 1 | 6.79 |
| CHEMBL1463659 | — | — | 1 | 6.68 |
| CHEMBL1163377 | — | — | 1 | 6.24 |
| CHEMBL2000517 | — | — | 1 | 6.16 |
| CHEMBL1877709 | — | — | 1 | 6.09 |
| CHEMBL1728280 | — | — | 1 | 6.07 |
| CHEMBL1384253 | — | — | 1 | 6.04 |
| CHEMBL1734083 | — | — | 1 | 5.97 |
| CHEMBL171632 | — | — | 1 | 5.89 |
| CHEMBL1432707 | — | — | 1 | 5.88 |
| CHEMBL417727 | — | — | 1 | 5.88 |
| CHEMBL1999630 | — | — | 1 | 5.85 |
| CHEMBL1998302 | — | — | 1 | 5.73 |
| CHEMBL51931 | 9,10-PHENANTHRENEQUINONE | — | 1 | 5.72 |
| CHEMBL3190880 | — | — | 1 | 5.66 |
| CHEMBL1969046 | — | — | 1 | 5.59 |
| CHEMBL1454614 | — | — | 1 | 5.59 |
| CHEMBL1735482 | — | — | 1 | 5.58 |
| CHEMBL1982305 | — | — | 1 | 5.50 |
| CHEMBL1501990 | — | — | 1 | 5.49 |
| CHEMBL3196451 | — | — | 1 | 5.48 |
| CHEMBL1706438 | — | — | 1 | 5.45 |
| CHEMBL1598762 | — | — | 1 | 5.45 |
| CHEMBL1378634 | — | — | 1 | 5.42 |
| CHEMBL1725485 | — | — | 1 | 5.39 |
| CHEMBL1577193 | — | — | 1 | 5.39 |
| CHEMBL1458321 | — | — | 1 | 5.38 |
| CHEMBL71466 | — | — | 1 | 5.35 |
| CHEMBL36536 | — | — | 1 | 5.34 |
| CHEMBL1733422 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1325945 | — | IC50 | = | 161.1 | nM | 6.79 |
| CHEMBL1463659 | — | IC50 | = | 210.04 | nM | 6.68 |
| CHEMBL1163377 | — | IC50 | = | 581.05 | nM | 6.24 |
| CHEMBL2000517 | — | IC50 | = | 697.64 | nM | 6.16 |
| CHEMBL1877709 | — | IC50 | = | 816.81 | nM | 6.09 |
| CHEMBL1728280 | — | IC50 | = | 842.48 | nM | 6.07 |
| CHEMBL1384253 | — | IC50 | = | 915.0 | nM | 6.04 |
| CHEMBL1734083 | — | IC50 | = | 1074.0 | nM | 5.97 |
| CHEMBL171632 | — | IC50 | = | 1273.0 | nM | 5.89 |
| CHEMBL417727 | — | IC50 | = | 1335.0 | nM | 5.88 |
| CHEMBL1432707 | — | IC50 | = | 1326.0 | nM | 5.88 |
| CHEMBL1999630 | — | IC50 | = | 1411.0 | nM | 5.85 |
| CHEMBL1998302 | — | IC50 | = | 1876.0 | nM | 5.73 |
| CHEMBL51931 | 9,10-PHENANTHRENEQUINONE | IC50 | = | 1907.0 | nM | 5.72 |
| CHEMBL3190880 | — | IC50 | = | 2198.0 | nM | 5.66 |
| CHEMBL1454614 | — | IC50 | = | 2546.0 | nM | 5.59 |
| CHEMBL1969046 | — | IC50 | = | 2575.0 | nM | 5.59 |
| CHEMBL1735482 | — | IC50 | = | 2661.0 | nM | 5.58 |
| CHEMBL1982305 | — | IC50 | = | 3184.0 | nM | 5.50 |
| CHEMBL1501990 | — | IC50 | = | 3266.0 | nM | 5.49 |
| CHEMBL3196451 | — | IC50 | = | 3297.0 | nM | 5.48 |
| CHEMBL1598762 | — | IC50 | = | 3525.0 | nM | 5.45 |
| CHEMBL1706438 | — | IC50 | = | 3521.0 | nM | 5.45 |
| CHEMBL1378634 | — | IC50 | = | 3847.0 | nM | 5.42 |
| CHEMBL1725485 | — | IC50 | = | 4028.0 | nM | 5.39 |
| CHEMBL1577193 | — | IC50 | = | 4113.0 | nM | 5.39 |
| CHEMBL1458321 | — | IC50 | = | 4202.0 | nM | 5.38 |
| CHEMBL71466 | — | IC50 | = | 4465.0 | nM | 5.35 |
| CHEMBL36536 | — | IC50 | = | 4598.0 | nM | 5.34 |
| CHEMBL1733422 | — | IC50 | = | 4777.0 | nM | 5.32 |
| CHEMBL1736254 | — | IC50 | = | 5037.0 | nM | 5.30 |
| CHEMBL1450897 | — | IC50 | = | 5074.0 | nM | 5.29 |
| CHEMBL1395907 | — | IC50 | = | 5320.0 | nM | 5.27 |
| CHEMBL1494979 | — | IC50 | = | 5361.0 | nM | 5.27 |
| CHEMBL1698802 | — | IC50 | = | 5453.0 | nM | 5.26 |
| CHEMBL175434 | — | IC50 | = | 5588.0 | nM | 5.25 |
| CHEMBL1376540 | — | IC50 | = | 5743.0 | nM | 5.24 |
| CHEMBL156174 | — | IC50 | = | 5986.0 | nM | 5.22 |
| CHEMBL1497070 | — | IC50 | = | 6222.0 | nM | 5.21 |
| CHEMBL3197208 | — | IC50 | = | 6482.0 | nM | 5.19 |
| CHEMBL3194086 | — | IC50 | = | 6561.0 | nM | 5.18 |
| CHEMBL3144856 | — | IC50 | = | 6907.0 | nM | 5.16 |
| CHEMBL2000196 | — | IC50 | = | 7665.0 | nM | 5.12 |
| CHEMBL1562466 | — | IC50 | = | 7520.0 | nM | 5.12 |
| CHEMBL1522941 | — | IC50 | = | 7657.0 | nM | 5.12 |
| CHEMBL478754 | — | IC50 | = | 7828.0 | nM | 5.11 |
| CHEMBL1405964 | — | IC50 | = | 7833.0 | nM | 5.11 |
| CHEMBL1502394 | — | IC50 | = | 8009.0 | nM | 5.10 |
| CHEMBL1726134 | — | IC50 | = | 8291.0 | nM | 5.08 |
| CHEMBL1698715 | — | IC50 | = | 8673.0 | nM | 5.06 |