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Assay Detail

CHEMBL4042877

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Functional
Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 by LDH assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Synthesis and biological characterisation of ester and amide derivatives of fusidic acid as antiplasmodial agents.
Espinoza-Moraga M, Singh K, Njoroge M, Kaur G, Okombo J, De Kock C, Smith PJ, Wittlin S, Chibale K.
Bioorg Med Chem Lett (2017) 27 : 658 -661
PubMed 28012840 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 5.70 8.03

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL361497 ARTESUNATE 4.0 1 8.03
CHEMBL76 CHLOROQUINE 4.0 1 7.59
CHEMBL4093908 1 5.92
CHEMBL4073226 1 5.92
CHEMBL4075052 1 5.85
CHEMBL4076938 1 5.75
CHEMBL4098522 1 5.70
CHEMBL4066457 1 5.68
CHEMBL4076105 1 5.64
CHEMBL4083011 1 5.62
CHEMBL4090915 1 5.62
CHEMBL4087783 1 5.58
CHEMBL4095485 1 5.58
CHEMBL4099448 1 5.54
CHEMBL4067603 1 5.54
CHEMBL4074523 1 5.52
CHEMBL4061132 1 5.50
CHEMBL4072532 1 5.47
CHEMBL4080502 1 5.46
CHEMBL4062455 1 5.44
CHEMBL4087466 1 5.34
CHEMBL4090800 1 5.33
CHEMBL4064641 1 4.87
CHEMBL374975 FUSIDIC ACID 3.0 1 4.23
CHEMBL4066092 1 -
CHEMBL4083635 1 -
CHEMBL4101636 1 -
CHEMBL4086151 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL361497 ARTESUNATE IC50 = 9.3 nM 8.03
CHEMBL76 CHLOROQUINE IC50 = 25.6 nM 7.59
CHEMBL4093908 IC50 = 1200.0 nM 5.92
CHEMBL4073226 IC50 = 1200.0 nM 5.92
CHEMBL4075052 IC50 = 1400.0 nM 5.85
CHEMBL4076938 IC50 = 1800.0 nM 5.75
CHEMBL4098522 IC50 = 2000.0 nM 5.70
CHEMBL4066457 IC50 = 2100.0 nM 5.68
CHEMBL4076105 IC50 = 2300.0 nM 5.64
CHEMBL4083011 IC50 = 2400.0 nM 5.62
CHEMBL4090915 IC50 = 2400.0 nM 5.62
CHEMBL4087783 IC50 = 2600.0 nM 5.58
CHEMBL4095485 IC50 = 2600.0 nM 5.58
CHEMBL4099448 IC50 = 2900.0 nM 5.54
CHEMBL4067603 IC50 = 2900.0 nM 5.54
CHEMBL4074523 IC50 = 3000.0 nM 5.52
CHEMBL4061132 IC50 = 3200.0 nM 5.50
CHEMBL4072532 IC50 = 3400.0 nM 5.47
CHEMBL4080502 IC50 = 3500.0 nM 5.46
CHEMBL4062455 IC50 = 3600.0 nM 5.44
CHEMBL4087466 IC50 = 4600.0 nM 5.34
CHEMBL4090800 IC50 = 4700.0 nM 5.33
CHEMBL4064641 IC50 = 13400.0 nM 4.87
CHEMBL374975 FUSIDIC ACID IC50 = 59000.0 nM 4.23
CHEMBL4066092 IC50 > 100000.0 nM -
CHEMBL4083635 IC50 > 100000.0 nM -
CHEMBL4101636 IC50 > 100000.0 nM -
CHEMBL4086151 IC50 > 100000.0 nM -