Compound Detail
CHEMBL356918
ENILCONAZOLE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL356918 |
| Name | ENILCONAZOLE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | PZBPKYOVPCNPJY-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
16
Publications
21
Known Names
Molecular Properties
297.2
MW (Da)
4.13
ALogP
3
HBA
0
HBD
27.1
PSA (Ų)
0.75
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Activity Summary
IC50 1 meas. best 4.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Indoleamine 2,3-dioxygenase 1 CHEMBL4685 | IC50 | 4.64 | 4.64 | 23000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Indoleamine 2,3-dioxygenase 1 | IC50 | = | 23000.0 | nM | 4.64 | Inhibition of IDO1 (unknown origin) using L-tryptophan substrate incubated for 6... | 25036789 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25036789 | 10.1016/j.ejmech.2014.06.078 | Indoleamine 2,3-dioxygenase 1 | 4 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.1016/S0960-894X(97)00046-2 | Adrenergic receptor beta | 1 |
| 16643045 | 10.1021/np0600595 | Aspergillus fumigatus | 1 |
| 16643045 | 10.1021/np0600595 | Candida albicans | 1 |
| 16643045 | 10.1021/np0600595 | Drechslera | 1 |
| 16643045 | 10.1021/np0600595 | Fusarium culmorum | 1 |
| 16643045 | 10.1021/np0600595 | Pseudomonas savastanoi pv. savastanoi | 1 |
| 16643045 | 10.1021/np0600595 | Staphylococcus aureus | 1 |
| - | 10.1016/j.cropro.2006.02.001 | Colletotrichum truncatum | 1 |
| 25036789 | 10.1016/j.ejmech.2014.06.078 | Tryptophan 2,3-dioxygenase | 1 |
| 25036789 | 10.1016/j.ejmech.2014.06.078 | ADMET | 1 |
| 25036789 | 10.1016/j.ejmech.2014.06.078 | No relevant target | 1 |
| - | 10.1101/2020.04.03.023846 | SARS-CoV-2 | 1 |
| - | 10.1101/2020.04.21.054387 | SARS-CoV-2 | 1 |
| 38318365 | 10.1016/j.isci.2024.108907 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 1 |
Data from ChEMBL 36 via Core Engine