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Assay Detail

CHEMBL1909169

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Binding
DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type BTI-TN-5B1-4
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] A (CHEMBL1951)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

DrugMatrix in vitro pharmacology data
Scott S. Auerbach, DrugMatrix¨ and ToxFX¨ Coordinator National Toxicology Program

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 871 5.66 7.23
Ki 871 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL311469 2-ACETYLAMINOFLUORENE 2 7.23
CHEMBL1089 PHENELZINE 4.0 2 6.84
CHEMBL577294 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN 3.0 2 6.78
CHEMBL698 TETRACAINE 4.0 2 6.50
CHEMBL165 RESVERATROL 3.0 2 6.35
CHEMBL828 PHENOTHIAZINE 2.0 2 6.23
CHEMBL55 PENTAMIDINE 4.0 2 6.10
CHEMBL1475 TRIOXSALEN 4.0 2 6.08
CHEMBL1070 NABUMETONE 4.0 2 6.00
CHEMBL420 GUANABENZ 4.0 2 5.75
CHEMBL1196 PROPARACAINE 4.0 2 5.75
CHEMBL398440 CHLOROXYLENOL 2.0 2 5.74
CHEMBL44 GENISTEIN 2.0 2 5.60
CHEMBL972 SELEGILINE 4.0 2 5.53
CHEMBL945 AMILORIDE 4.0 2 5.41
CHEMBL1200624 ETHYNODIOL DIACETATE 4.0 2 5.37
CHEMBL31184 BENZO[DEF]CHRYSENE 0.5 2 5.22
CHEMBL964 DISULFIRAM 4.0 2 4.86
CHEMBL960 LEFLUNOMIDE 4.0 2 4.68
CHEMBL1381098 1-NAPHTHYLISOTHIOCYANATE 2 4.65
CHEMBL9514 NOCODAZOLE 2.0 2 4.62
CHEMBL7002 CIGLITAZONE 2.0 2 4.54
CHEMBL595 PIOGLITAZONE 4.0 2 4.46
CHEMBL1200558 BACITRACIN 4.0 2 -
CHEMBL388590 BENZBROMARONE 4.0 2 -
CHEMBL844 BRIMONIDINE 4.0 2 -
CHEMBL1200396 BUPIVACAINE HYDROCHLORIDE 4.0 2 -
CHEMBL1458880 CADMIUM DICHLORIDE 2 -
CHEMBL14 CARBACHOL 4.0 2 -
CHEMBL211501 ANTIMYCIN A 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL311469 2-ACETYLAMINOFLUORENE IC50 = 59.0 nM 7.23
CHEMBL1089 PHENELZINE IC50 = 146.0 nM 6.84
CHEMBL577294 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN IC50 = 167.0 nM 6.78
CHEMBL698 TETRACAINE IC50 = 317.0 nM 6.50
CHEMBL165 RESVERATROL IC50 = 449.0 nM 6.35
CHEMBL828 PHENOTHIAZINE IC50 = 592.0 nM 6.23
CHEMBL55 PENTAMIDINE IC50 = 793.0 nM 6.10
CHEMBL1475 TRIOXSALEN IC50 = 831.0 nM 6.08
CHEMBL1070 NABUMETONE IC50 = 998.0 nM 6.00
CHEMBL1196 PROPARACAINE IC50 = 1777.0 nM 5.75
CHEMBL420 GUANABENZ IC50 = 1787.0 nM 5.75
CHEMBL398440 CHLOROXYLENOL IC50 = 1829.0 nM 5.74
CHEMBL44 GENISTEIN IC50 = 2520.0 nM 5.60
CHEMBL972 SELEGILINE IC50 = 2984.0 nM 5.53
CHEMBL945 AMILORIDE IC50 = 3909.0 nM 5.41
CHEMBL1200624 ETHYNODIOL DIACETATE IC50 = 4290.0 nM 5.37
CHEMBL31184 BENZO[DEF]CHRYSENE IC50 = 5972.0 nM 5.22
CHEMBL964 DISULFIRAM IC50 = 13734.0 nM 4.86
CHEMBL960 LEFLUNOMIDE IC50 = 20696.0 nM 4.68
CHEMBL1381098 1-NAPHTHYLISOTHIOCYANATE IC50 = 22442.0 nM 4.65
CHEMBL9514 NOCODAZOLE IC50 = 24099.0 nM 4.62
CHEMBL7002 CIGLITAZONE IC50 = 29193.0 nM 4.54
CHEMBL595 PIOGLITAZONE IC50 = 35069.0 nM 4.46
CHEMBL2106399 KITASAMYCIN Ki - -
CHEMBL741 LAMOTRIGINE IC50 - -
CHEMBL741 LAMOTRIGINE Ki - -
CHEMBL1201237 LEVOBUNOLOL IC50 - -
CHEMBL91 MICONAZOLE IC50 - -
CHEMBL164290 N-NITROSODIETHYLAMINE IC50 - -
CHEMBL164290 N-NITROSODIETHYLAMINE Ki - -
CHEMBL313493 METHANESULFONIC ACID METHYL ESTER IC50 - -
CHEMBL313493 METHANESULFONIC ACID METHYL ESTER Ki - -
CHEMBL878 METOLAZONE IC50 - -
CHEMBL878 METOLAZONE Ki - -
CHEMBL80 NALOXONE Ki - -
CHEMBL1513 IRBESARTAN Ki - -
CHEMBL2106399 KITASAMYCIN IC50 - -
CHEMBL64391 ITRACONAZOLE Ki - -
CHEMBL64391 ITRACONAZOLE IC50 - -
CHEMBL92401 IPRONIAZID Ki - -
CHEMBL92401 IPRONIAZID IC50 - -
CHEMBL1618305 NALOXONAZINE Ki - -
CHEMBL1618305 NALOXONAZINE IC50 - -
CHEMBL6437 MIANSERIN Ki - -
CHEMBL6437 MIANSERIN IC50 - -
CHEMBL86 METOCLOPRAMIDE Ki - -
CHEMBL86 METOCLOPRAMIDE IC50 - -
CHEMBL1354199 METHSCOPOLAMINE BROMIDE Ki - -
CHEMBL975 MESNA Ki - -
CHEMBL1354199 METHSCOPOLAMINE BROMIDE IC50 - -