Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL975

MESNA
💊 Approved Drug
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
💊 Approved Drug
O=S(=O)([O-])CCS.[Na+]
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL975
Name MESNA
Phase Approved
Structure Type MOL
InChI Key XOGTZOOQQBDUSI-UHFFFAOYSA-M
Therapeutic ✓ Yes
Parent Compound CHEMBL1098319
Active Moiety CHEMBL1098319

Known Names

Coenzyme m sodium salt D 7093 D-7093 Mesna Mesnex Mistabron NSC-113891 Uromitexan
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
20
Publications
8
Known Names
20
Indications
1
Mechanisms

Molecular Properties

142.2
MW (Da)
-0.20
ALogP
3
HBA
2
HBD
54.4
PSA (Ų)
0.41
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1988
Availability Prescription
Chirality Achiral

Routes of Administration

Oral Parenteral
USAN Year 1990

Extended Properties

Molecular Formula C2H5NaO3S2
MW 164.18
Aromatic Rings 0
Heavy Atoms 7
NP-Likeness 0.01

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Unknown - - ✓ ✓

Indications

Thrombocytopenia Brain Neoplasms Breast Neoplasms Breast Neoplasms Ependymoma Ependymoma Leukemia Leukemia, Lymphoid Lung Neoplasms Lymphoma Lymphoma, Large B-Cell, Diffuse Medulloblastoma Multiple Sclerosis, Relapsing-Remitting Neuroblastoma Sarcoma Sarcoma Scleroderma, Systemic Acute Kidney Injury Anemia, Aplastic Anemia, Sickle Cell

ATC Classification

R05CB05
mesna
Level 1: RESPIRATORY SYSTEM
Level 2: COUGH AND COLD PREPARATIONS
V03AF01
mesna
Level 1: VARIOUS
Level 2: ALL OTHER THERAPEUTIC PRODUCTS

Literature References

PubMed DOI Target Context # Activities
- 10.6019/CHEMBL3885881 Rattus norvegicus 320
16472241 10.2174/1570163043334794 Hepatotoxicity 18
22194678 10.1371/journal.pcbi.1002310 Hepatotoxicity 14
7853342 10.1021/jm00003a012 Mus musculus 6
34846885 10.1021/acs.jmedchem.1c01333 ADMET 3
17499885 10.1016/j.ejmech.2007.03.010 ADMET 3
20014752 10.1021/tx900326k Hepatotoxicity 3
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
26948801 10.1016/j.drudis.2016.02.015 Homo sapiens 2
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B1 1
- 10.1101/2020.04.03.023846 SARS-CoV-2 1
23956101 10.1093/toxsci/kft176 ATP-binding cassette sub-family C member 4 1
23956101 10.1093/toxsci/kft176 ATP-binding cassette sub-family C member 3 1
23956101 10.1093/toxsci/kft176 ATP-binding cassette sub-family C member 2 1
23956101 10.1093/toxsci/kft176 Bile salt export pump 1
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B3 1
20022146 10.1016/j.ejmech.2009.11.034 Homo sapiens 1
17499885 10.1016/j.ejmech.2007.03.010 HL-60 1
17499885 10.1016/j.ejmech.2007.03.010 HSC-4 1
17499885 10.1016/j.ejmech.2007.03.010 HSC-2 1

Data from ChEMBL 36 via Core Engine