Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1247376

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant VAP-1 expressed in CHO cells after 30 mins by coupled colorimetric method
ChEMBL ↗
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [copper-containing] 3 (CHEMBL3437) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis, in vitro activity, and three-dimensional quantitative structure-activity relationship of novel hydrazine inhibitors of human vascular adhesion protein-1.
Nurminen EM, Pihlavisto M, Lázár L, Szakonyi Z, Pentikäinen U, Fülöp F, Pentikäinen OT.
J Med Chem (2010) 53 : 6301 -6315
PubMed 20690686 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 52 6.64 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1089 PHENELZINE 4.0 1 7.70
CHEMBL1241119 — — 1 7.54
CHEMBL1241071 — — 1 7.28
CHEMBL1241428 — — 1 7.23
CHEMBL1240954 — — 1 7.22
CHEMBL1241070 — — 1 7.19
CHEMBL1240910 — — 1 7.15
CHEMBL1241004 — — 1 7.10
CHEMBL1240912 — — 1 7.05
CHEMBL1240878 — — 1 7.04
CHEMBL1240877 — — 1 6.96
CHEMBL1240879 — — 1 6.96
CHEMBL1240909 — — 1 6.92
CHEMBL1240908 — — 1 6.77
CHEMBL1241003 — — 1 6.74
CHEMBL1241167 — — 1 6.70
CHEMBL1241120 — — 1 6.68
CHEMBL1241166 — — 1 6.66
CHEMBL1241378 — — 1 6.64
CHEMBL1241069 — — 1 6.62
CHEMBL1241068 — — 1 6.59
CHEMBL1241289 — — 1 6.59
CHEMBL1241263 — — 1 6.59
CHEMBL1241379 — — 1 6.57
CHEMBL1241121 — — 1 6.57
CHEMBL1241123 — — 1 6.55
CHEMBL1241122 — — 1 6.51
CHEMBL1241164 — — 1 6.51
CHEMBL1241165 — — 1 6.49
CHEMBL1241330 — — 1 6.49

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1089 PHENELZINE IC50 = 19.95 nM 7.70
CHEMBL1241119 — IC50 = 28.84 nM 7.54
CHEMBL1241071 — IC50 = 52.48 nM 7.28
CHEMBL1241428 — IC50 = 58.88 nM 7.23
CHEMBL1240954 — IC50 = 60.26 nM 7.22
CHEMBL1241070 — IC50 = 64.57 nM 7.19
CHEMBL1240910 — IC50 = 70.79 nM 7.15
CHEMBL1241004 — IC50 = 79.43 nM 7.10
CHEMBL1240912 — IC50 = 89.13 nM 7.05
CHEMBL1240878 — IC50 = 91.2 nM 7.04
CHEMBL1240877 — IC50 = 109.65 nM 6.96
CHEMBL1240879 — IC50 = 109.65 nM 6.96
CHEMBL1240909 — IC50 = 120.23 nM 6.92
CHEMBL1240908 — IC50 = 169.82 nM 6.77
CHEMBL1241003 — IC50 = 181.97 nM 6.74
CHEMBL1241167 — IC50 = 199.53 nM 6.70
CHEMBL1241120 — IC50 = 208.93 nM 6.68
CHEMBL1241166 — IC50 = 218.78 nM 6.66
CHEMBL1241378 — IC50 = 229.09 nM 6.64
CHEMBL1241069 — IC50 = 239.88 nM 6.62
CHEMBL1241068 — IC50 = 257.04 nM 6.59
CHEMBL1241289 — IC50 = 257.04 nM 6.59
CHEMBL1241263 — IC50 = 257.04 nM 6.59
CHEMBL1241379 — IC50 = 269.15 nM 6.57
CHEMBL1241121 — IC50 = 269.15 nM 6.57
CHEMBL1241123 — IC50 = 281.84 nM 6.55
CHEMBL1241164 — IC50 = 309.03 nM 6.51
CHEMBL1241122 — IC50 = 309.03 nM 6.51
CHEMBL1241165 — IC50 = 323.59 nM 6.49
CHEMBL1241330 — IC50 = 323.59 nM 6.49
CHEMBL1241002 — IC50 = 323.59 nM 6.49
CHEMBL1240957 — IC50 = 331.13 nM 6.48
CHEMBL1241430 — IC50 = 346.74 nM 6.46
CHEMBL1240911 — IC50 = 346.74 nM 6.46
CHEMBL1241261 — IC50 = 346.74 nM 6.46
CHEMBL1241262 — IC50 = 346.74 nM 6.46
CHEMBL1240956 — IC50 = 346.74 nM 6.46
CHEMBL1240955 — IC50 = 371.54 nM 6.43
CHEMBL1243019 — IC50 = 389.05 nM 6.41
CHEMBL1241377 — IC50 = 398.11 nM 6.40
CHEMBL1241293 — IC50 = 407.38 nM 6.39
CHEMBL1241331 — IC50 = 407.38 nM 6.39
CHEMBL1241332 — IC50 = 416.87 nM 6.38
CHEMBL1241329 — IC50 = 426.58 nM 6.37
CHEMBL1241260 — IC50 = 426.58 nM 6.37
CHEMBL1241291 — IC50 = 436.52 nM 6.36
CHEMBL1241067 — IC50 = 436.52 nM 6.36
CHEMBL1241429 — IC50 = 467.74 nM 6.33
CHEMBL1241290 — IC50 = 562.34 nM 6.25
CHEMBL1241292 — IC50 = 575.44 nM 6.24