Assay Detail
Binding
CHEMBL4042110
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human MAO-A assessed as reduction in 4-hydroxyquinoline formation using kynuramine as substrate after 20 mins by fluorometric assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Isolation of Acacetin from Calea urticifolia with Inhibitory Properties against Human Monoamine Oxidase-A and -B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.45 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL243664 | ACACETIN | — | 1 | 6.92 |
| CHEMBL309490 | GALANGIN | — | 1 | 6.89 |
| CHEMBL1089 | PHENELZINE | 4.0 | 1 | 6.62 |
| CHEMBL28 | APIGENIN | — | 1 | 6.19 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL243664 | ACACETIN | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL309490 | GALANGIN | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1089 | PHENELZINE | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL28 | APIGENIN | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL50 | QUERCETIN | IC50 | = | 2440.0 | nM | 5.61 |