Voltage-dependent L-type calcium channel subunit alpha-1C · SINGLE PROTEIN · Rattus norvegicus
This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.
Move to another high-traffic target or paste a specific ChEMBL target ID.
Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt P22002. Use UniProt P22002 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P22002 as the stable identity anchor, then attach disease evidence before program review.
Voltage-dependent L-type calcium channel subunit alpha-1C
Review this target as Voltage-dependent L-type calcium channel subunit alpha-1C, mapped to UniProt P22002. Sequence length is 2169 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Voltage-dependent L-type calcium channel subunit alpha-1C as ChEMBL target CHEMBL3762, mapped to UniProt P22002. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Voltage-dependent L-type calcium channel subunit alpha-1C is the right protein anchor across sources, using UniProt P22002 as the stable mapping.
Jump to Protein ContextUse this block first when you need the strongest disease program and evidence level in one place.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Voltage-dependent L-type calcium channel subunit alpha-1C |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P22002 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Voltage-dependent L-type calcium channel subunit alpha-1C |
| UniProt Accession | P22002 |
| Component Type | Protein |
| Sequence Length | 2169 aa |
Voltage-dependent L-type calcium channel subunit alpha-1C
Review this target as Voltage-dependent L-type calcium channel subunit alpha-1C, mapped to UniProt P22002. Sequence length is 2169 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL193 | 8.85 | IC50 | 1.42 | Approved |
| CHEMBL1491 | 8.7 | Ki | 2.0 | Approved |
| CHEMBL104455 | 8.67 | Ki | 2.16 | Preclinical |
| CHEMBL3350845 | 8.67 | Ki | 2.15 | Preclinical |
| CHEMBL3350842 | 8.62 | Ki | 2.4 | Preclinical |
| CHEMBL193 | 8.46 | Ki | 3.5 | Approved |
| CHEMBL325811 | 8.25 | Ki | 5.63 | Preclinical |
| CHEMBL3350227 | 8.1 | Ki | 8.0 | Preclinical |
| CHEMBL24675 | 8.08 | Ki | 8.3 | Preclinical |
| CHEMBL104082 | 8.06 | Ki | 8.69 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 46 | 2 | 7.4 |
| tissue-based format | 9 | 19 | 6.9 |
| assay format | 8 | 1 | 5.5 |
| cell membrane format | 7 | 16 | 7.2 |
| cell-based format | 7 | 30 | 6.2 |
| protein format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 64 | 51 | 5.3 |
| tissue-based format | 8 | 26 | 6.2 |
| assay format | 5 | 7 | 7.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 1 | 0 | — |