Assay Detail
Functional
CHEMBL1040691
Review assay metadata, readout intent, target linkage, and publication context from the same page.
NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay
5697
Total Activities
5614
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5697 | 6.29 | 9.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL535468 | — | — | 1 | 9.23 |
| CHEMBL544227 | CHLORCYCLOGUANIL HYDROCHLORIDE | — | 1 | 9.01 |
| CHEMBL585665 | — | — | 1 | 8.91 |
| CHEMBL529837 | — | — | 2 | 8.62 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.62 |
| CHEMBL578074 | — | — | 1 | 8.61 |
| CHEMBL580164 | — | — | 1 | 8.61 |
| CHEMBL602389 | — | — | 1 | 8.61 |
| CHEMBL531990 | — | — | 1 | 8.55 |
| CHEMBL600913 | — | — | 1 | 8.51 |
| CHEMBL602209 | — | — | 1 | 8.48 |
| CHEMBL596653 | — | — | 1 | 8.46 |
| CHEMBL581886 | CEPHAELINE HYDROBROMIDE | — | 1 | 8.44 |
| CHEMBL576350 | — | — | 1 | 8.41 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.39 |
| CHEMBL578283 | — | — | 1 | 8.30 |
| CHEMBL578706 | — | — | 1 | 8.25 |
| CHEMBL597470 | — | — | 1 | 8.25 |
| CHEMBL585656 | — | — | 1 | 8.23 |
| CHEMBL591861 | — | — | 1 | 8.21 |
| CHEMBL577200 | — | — | 1 | 8.20 |
| CHEMBL601785 | — | — | 1 | 8.18 |
| CHEMBL580353 | — | — | 1 | 8.17 |
| CHEMBL579338 | — | — | 1 | 8.17 |
| CHEMBL577445 | — | — | 1 | 8.16 |
| CHEMBL576205 | — | — | 1 | 8.15 |
| CHEMBL600715 | — | — | 1 | 8.15 |
| CHEMBL535267 | — | — | 1 | 8.14 |
| CHEMBL602823 | — | — | 1 | 8.14 |
| CHEMBL317364 | — | — | 1 | 8.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL535468 | — | EC50 | = | 0.592 | nM | 9.23 |
| CHEMBL544227 | CHLORCYCLOGUANIL HYDROCHLORIDE | EC50 | = | 0.986 | nM | 9.01 |
| CHEMBL585665 | — | EC50 | = | 1.231 | nM | 8.91 |
| CHEMBL76 | CHLOROQUINE | EC50 | = | 2.426 | nM | 8.62 |
| CHEMBL529837 | — | EC50 | = | 2.428 | nM | 8.62 |
| CHEMBL580164 | — | EC50 | = | 2.435 | nM | 8.61 |
| CHEMBL578074 | — | EC50 | = | 2.444 | nM | 8.61 |
| CHEMBL602389 | — | EC50 | = | 2.431 | nM | 8.61 |
| CHEMBL531990 | — | EC50 | = | 2.792 | nM | 8.55 |
| CHEMBL600913 | — | EC50 | = | 3.102 | nM | 8.51 |
| CHEMBL602209 | — | EC50 | = | 3.34 | nM | 8.48 |
| CHEMBL596653 | — | EC50 | = | 3.49 | nM | 8.46 |
| CHEMBL581886 | CEPHAELINE HYDROBROMIDE | EC50 | = | 3.61 | nM | 8.44 |
| CHEMBL576350 | — | EC50 | = | 3.91 | nM | 8.41 |
| CHEMBL94657 | PATUPILONE | EC50 | = | 4.09 | nM | 8.39 |
| CHEMBL578283 | — | EC50 | = | 5.05 | nM | 8.30 |
| CHEMBL578706 | — | EC50 | = | 5.64 | nM | 8.25 |
| CHEMBL597470 | — | EC50 | = | 5.58 | nM | 8.25 |
| CHEMBL585656 | — | EC50 | = | 5.93 | nM | 8.23 |
| CHEMBL591861 | — | EC50 | = | 6.21 | nM | 8.21 |
| CHEMBL577200 | — | EC50 | = | 6.3 | nM | 8.20 |
| CHEMBL601785 | — | EC50 | = | 6.55 | nM | 8.18 |
| CHEMBL580353 | — | EC50 | = | 6.82 | nM | 8.17 |
| CHEMBL579338 | — | EC50 | = | 6.71 | nM | 8.17 |
| CHEMBL577445 | — | EC50 | = | 6.92 | nM | 8.16 |
| CHEMBL600715 | — | EC50 | = | 7.05 | nM | 8.15 |
| CHEMBL576205 | — | EC50 | = | 7.08 | nM | 8.15 |
| CHEMBL579292 | — | EC50 | = | 7.21 | nM | 8.14 |
| CHEMBL535267 | — | EC50 | = | 7.23 | nM | 8.14 |
| CHEMBL602823 | — | EC50 | = | 7.31 | nM | 8.14 |
| CHEMBL317364 | — | EC50 | = | 7.16 | nM | 8.14 |
| CHEMBL585896 | — | EC50 | = | 7.17 | nM | 8.14 |
| CHEMBL600942 | — | EC50 | = | 7.62 | nM | 8.12 |
| CHEMBL7568 | QUINACRINE | EC50 | = | 8.13 | nM | 8.09 |
| CHEMBL579905 | — | EC50 | = | 8.24 | nM | 8.08 |
| CHEMBL600313 | — | EC50 | = | 8.99 | nM | 8.05 |
| CHEMBL533376 | — | EC50 | = | 8.92 | nM | 8.05 |
| CHEMBL602164 | — | EC50 | = | 8.92 | nM | 8.05 |
| CHEMBL531150 | — | EC50 | = | 8.94 | nM | 8.05 |
| CHEMBL580146 | — | EC50 | = | 9.08 | nM | 8.04 |
| CHEMBL578738 | — | EC50 | = | 9.45 | nM | 8.03 |
| CHEMBL1294 | QUINIDINE | EC50 | = | 9.59 | nM | 8.02 |
| CHEMBL579077 | — | EC50 | = | 9.53 | nM | 8.02 |
| CHEMBL586825 | — | EC50 | = | 9.8 | nM | 8.01 |
| CHEMBL423192 | ANISOMYCIN | EC50 | = | 9.75 | nM | 8.01 |
| CHEMBL609748 | — | EC50 | = | 9.86 | nM | 8.01 |
| CHEMBL578884 | — | EC50 | = | 9.98 | nM | 8.00 |
| CHEMBL50588 | EMETINE | EC50 | = | 10.15 | nM | 7.99 |
| CHEMBL1630 | — | EC50 | = | 10.29 | nM | 7.99 |
| CHEMBL521079 | — | EC50 | = | 10.63 | nM | 7.97 |