Cholinesterase · SINGLE PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13Protein identity stays anchored to UniProt P06276. Use UniProt P06276 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P06276 as the stable identity anchor, then attach disease evidence before program review.
Cholinesterase
Review this target as Cholinesterase, mapped to UniProt P06276. Sequence length is 602 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cholinesterase as ChEMBL target CHEMBL1914, mapped to UniProt P06276. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Cholinesterase is the right protein anchor across sources, using UniProt P06276 as the stable mapping.
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| Preferred Name | Cholinesterase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P06276 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cholinesterase |
| UniProt Accession | P06276 |
| Component Type | Protein |
| Sequence Length | 602 aa |
Cholinesterase
Review this target as Cholinesterase, mapped to UniProt P06276. Sequence length is 602 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4080419 | 10.95 | Ki | 0.0111 | Preclinical |
| CHEMBL1814730 | 10.67 | IC50 | 0.0212 | Preclinical |
| CHEMBL95 | 10.57 | IC50 | 0.0267 | Approved |
| CHEMBL224336 | 10.52 | IC50 | 0.03 | Preclinical |
| CHEMBL1814731 | 10.45 | IC50 | 0.0354 | Preclinical |
| CHEMBL5080685 | 10.45 | IC50 | 0.0352 | Preclinical |
| CHEMBL2019034 | 10.42 | IC50 | 0.038 | Preclinical |
| CHEMBL5201089 | 10.41 | IC50 | 0.039 | Preclinical |
| CHEMBL1814729 | 10.35 | IC50 | 0.0449 | Preclinical |
| CHEMBL3099496 | 10.22 | Ki | 0.06 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 827 | 3,301 | 6.1 |
| cell-free format | 128 | 579 | 6.3 |
| cell-based format | 16 | 18 | 6.0 |
| assay format | 9 | 29 | 6.5 |
| tissue-based format | 5 | 19 | 6.6 |
| microsome format | 2 | 21 | 7.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 9 | 12 | 5.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 1 | 0 | — |