Compound Detail
CHEMBL1206
ETHOPROPAZINE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1206 |
| Name | ETHOPROPAZINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | CDOZDBSBBXSXLB-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
6
Targets
16
Activities
2
Assay Types
0
PK Parameters
20
Publications
5
Known Names
1
Indications
Molecular Properties
312.5
MW (Da)
5.02
ALogP
3
HBA
0
HBD
6.5
PSA (Ų)
0.77
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1982 |
| Availability | Discontinued |
| Chirality | Racemic |
Indications
Parkinson Disease
ATC Classification
N04AA05
profenamine
Level 1: NERVOUS SYSTEM
Level 2: ANTI-PARKINSON DRUGS
Activity Summary
IC50 11 meas. best 6.68
Ki 5 meas. best 7.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cholinesterase CHEMBL1914 | Ki | 7.7 | 7.7 | 20.0 | 2 |
| Butyrylcholinesterase CHEMBL5077 | Ki | 7.7 | 7.7 | 20.0 | 1 |
| Cholinesterase CHEMBL1914 | IC50 | 6.68 | 6.6 | 210.0 | 2 |
| Acetylcholinesterase CHEMBL220 | IC50 | 6.58 | 6.55 | 260.0 | 4 |
| Cholinesterase CHEMBL5763 | IC50 | 6.14 | 6.14 | 720.0 | 1 |
| Chikungunya virus CHEMBL4296563 | IC50 | 4.8 | 4.8 | 16000.0 | 1 |
| Solute carrier family 22 member 1 CHEMBL5685 | IC50 | 4.69 | 4.69 | 20460.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine