Assay Detail
Binding
CHEMBL5142617
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Inhibition of human BChE assessed as inhibition constant
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
<i>N</i>-Benzyl Benzamide Derivatives as Selective Sub-Nanomolar Butyrylcholinesterase Inhibitors for Possible Treatment in Advanced Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.88 | 10.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5201089 | — | — | 1 | 10.03 |
| CHEMBL5195228 | — | — | 1 | 9.21 |
| CHEMBL1206 | ETHOPROPAZINE | 4.0 | 1 | 7.70 |
| CHEMBL332935 | — | — | 1 | 6.37 |
| CHEMBL224392 | THIOFLAVIN T | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5201089 | — | Ki | = | 0.094 | nM | 10.03 |
| CHEMBL5195228 | — | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL1206 | ETHOPROPAZINE | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL332935 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL224392 | THIOFLAVIN T | Ki | = | 800.0 | nM | 6.10 |