Assay Detail
Binding
CHEMBL3375254
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Inhibition of AChE (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.24 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.72 |
| CHEMBL1206 | ETHOPROPAZINE | 4.0 | 1 | 6.58 |
| CHEMBL129837 | 4-ISOPROPYLPHENSERINE | — | 1 | 6.12 |
| CHEMBL636 | RIVASTIGMINE | 4.0 | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1206 | ETHOPROPAZINE | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL129837 | 4-ISOPROPYLPHENSERINE | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL636 | RIVASTIGMINE | IC50 | = | 3030.0 | nM | 5.52 |