Acetylcholinesterase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Acetylcholinesterase shows approved-linked disease relevance led by Alzheimer disease. 5 more disease programs remain visible in the same review block. 4 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P22303. Start with Alzheimer disease, then reuse UniProt P22303 as the stable protein anchor across project notes and exports.
Start with Alzheimer disease, then reuse UniProt P22303 as the stable protein anchor across project notes and exports.
Acetylcholinesterase shows approved-linked disease relevance led by Alzheimer disease. 5 more disease programs remain visible in the same review block. 4 linked drugs remain visible in the same block.
Start review with Alzheimer disease because it currently carries approved-linked support. Linked drugs include BENZGALANTAMINE GLUCONATE, DONEPEZIL HYDROCHLORIDE, GALANTAMINE HYDROBROMIDE, HUPERZINE A. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyAcetylcholinesterase
Review this target as Acetylcholinesterase, mapped to UniProt P22303. Sequence length is 614 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Acetylcholinesterase as ChEMBL target CHEMBL220, mapped to UniProt P22303. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Acetylcholinesterase is the right protein anchor across sources, using UniProt P22303 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Alzheimer disease is currently framed as approved-linked support. It currently carries 4 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Acetylcholinesterase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P22303 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Acetylcholinesterase |
| UniProt Accession | P22303 |
| Component Type | Protein |
| Sequence Length | 614 aa |
Acetylcholinesterase
Review this target as Acetylcholinesterase, mapped to UniProt P22303. Sequence length is 614 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Acetylcholinesterase shows approved-linked disease relevance led by Alzheimer disease. 5 more disease programs remain visible in the same review block.
Start review with Alzheimer disease because it currently carries approved-linked support. Linked drugs include BENZGALANTAMINE GLUCONATE, DONEPEZIL HYDROCHLORIDE, GALANTAMINE HYDROBROMIDE, HUPERZINE A. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3585779 | 10.98 | Ki | 0.0105 | Preclinical |
| CHEMBL4205425 | 10.96 | IC50 | 0.01095 | Preclinical |
| CHEMBL489454 | 10.93 | Ki | 0.0118 | Preclinical |
| CHEMBL4205954 | 10.88 | IC50 | 0.01323 | Preclinical |
| CHEMBL4209803 | 10.87 | IC50 | 0.01352 | Preclinical |
| CHEMBL225567 | 10.85 | Ki | 0.014 | Preclinical |
| CHEMBL4217663 | 10.85 | IC50 | 0.01415 | Preclinical |
| CHEMBL4210316 | 10.84 | IC50 | 0.01441 | Preclinical |
| CHEMBL223443 | 10.82 | Ki | 0.015 | Preclinical |
| CHEMBL4214430 | 10.78 | IC50 | 0.01672 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1,847 | 5,269 | 6.3 |
| cell-based format | 189 | 568 | 6.2 |
| assay format | 166 | 445 | 6.6 |
| tissue-based format | 30 | 106 | 5.9 |
| cell membrane format | 28 | 1 | 6.9 |
| organism-based format | 14 | 0 | — |
| cell-free format | 5 | 34 | 5.3 |
| subcellular format | 1 | 2 | 6.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 19 | 78 | 5.4 |
| cell-based format | 5 | 30 | 5.8 |
| cell membrane format | 2 | 0 | — |
| assay format | 1 | 22 | 4.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 18 | 53 | 6.3 |
| cell-based format | 2 | 0 | — |
| organism-based format | 1 | 0 | — |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 30 | — |