Compound Detail
CHEMBL1201217
DYCLONINE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1201217 |
| Name | DYCLONINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | BZEWSEKUUPWQDQ-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
20
Publications
2
Known Names
Molecular Properties
289.4
MW (Da)
3.92
ALogP
3
HBA
0
HBD
29.5
PSA (Ų)
0.54
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1982 |
| Availability | Prescription |
| Chirality | Achiral |
ATC Classification
N01BX02
dyclonine
Level 1: NERVOUS SYSTEM
Level 2: ANESTHETICS
R02AD04
dyclonine
Level 1: RESPIRATORY SYSTEM
Level 2: THROAT PREPARATIONS
Activity Summary
IC50 3 meas. best 6.74
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Acetylcholinesterase CHEMBL220 | IC50 | 6.74 | 6.74 | 181.0 | 1 |
| Transient receptor potential cation channel subfamily V member 3 CHEMBL3879838 | IC50 | 5.5 | 5.5 | 3200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Acetylcholinesterase | IC50 | = | 181.0 | nM | 6.74 | Inhibition of AChE (unknown origin) | 29429576 |
| Transient receptor potential cation channel subfamily V member 3 | IC50 | = | 3200.0 | nM | 5.5 | Inhibition of mouse TRPV3 expressed in HEK293 cells assessed as reduction in 2-A... | 38961616 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-1A adrenergic receptor | 4 |
| 37468498 | 10.1038/s41467-023-40064-9 | Cannabinoid receptor 1 | 4 |
| 37468498 | 10.1038/s41467-023-40064-9 | 5-hydroxytryptamine receptor 1A | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | 5-hydroxytryptamine receptor 2B | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | Muscarinic acetylcholine receptor M2 | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-2A adrenergic receptor | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | 5-hydroxytryptamine receptor 2A | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | Histamine H1 receptor | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | Gamma-aminobutyric acid receptor subunit alpha-1 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Beta-2 adrenergic receptor | 2 |
| 38961616 | 10.1021/acs.jnatprod.4c00626 | Mus musculus | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | D(1A) dopamine receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Histamine H2 receptor | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | 5-hydroxytryptamine receptor 6 | 1 |
| 29429576 | 10.1016/j.bmc.2018.01.029 | Acetylcholinesterase | 1 |
Data from ChEMBL 36 via Core Engine